Table 4.
Genotype-specific ulcerative colitis odds ratios (with 95%CI) for combinations of variants in IL23R and IBD5
|
SLC22A4 |
SLC22A5 |
IGR2230a_1 |
IGR2198a_1 |
IGR2096a_1 |
||||||
| CC | CT + TT | GG | GC + CC | GG | AG + AA | GG | GC + CC | GG | GT + TT | |
| IL23R rs1004819 | ||||||||||
| GG | 1 | 1.298 | 1 | 1.064 | 1 | 0.941 | 1 | 1.033 | 1 | 1.104 |
| (0.782-2.156) | (0.623-1.815) | (0.556-1.593) | (0.623-1.711) | (0.666-1.831) | ||||||
| P = 0.313 | P = 0.821 | P = 0.822 | P = 0.900 | P = 0.702 | ||||||
| GA + AA | 1.527 | 12.015 | 1.424 | 11.691 | 1.300 | 1.549 | 1.263 | 11.803 | 1.281 | 11.911 |
| (0.872-2.673) | (1.230-3.300) | (0.776-2.614) | (1.003-2.821) | (0.716-2.359) | (0.927-2.588) | (0.736-2.166) | (1.096-2.966) | (0.744-2.206) | (1.162-3.143) | |
| P = 0.138 | P = 0.005 | P = 0.253 | P = 0.048 | P = 0.388 | P = 0.093 | P = 0.396 | P = 0.020 | P = 0.372 | P = 0.010 | |
| IL23R rs2201841 | ||||||||||
| TT+TC | 1 | 1.328 | 1 | 1.254 | 1 | 1.184 | 1 | 1.296 | 1 | 1.385 |
| (0.989-1.927) | (0.868-1.812 | (0.823-1.704) | (0.922-1.822) | (0.982-1.953) | ||||||
| P = 0.058 | P = 0.228 | P = 0.363 | P = 0.136 | P = 0.063 | ||||||
| CC | 13.413 | 1.716 | 13.946 | 1.474 | 13.777 | 1.411 | 13.165 | 1.592 | 12.977 | 11.701 |
| (1.169-9.965) | (0.788-3.739 | (1.232-12.645) | (0.679-3.200) | (1.181-12.084) | (0.652-3.056) | (1.088-9.206) | (0.735-3.449) | (1.099-8.066) | (0.765-3.784) | |
| P = 0.018 | P = 0.171 | P = 0.014 | P = 0.324 | P = 0.018 | P = 0.381 | P = 0.027 | P = 0.236 | P = 0.026 | P = 0.189 | |
1
Associations significant at P < 0.05 vs controls.