. 2014 Jan 7;20(1):250–257. doi: 10.3748/wjg.v20.i1.250

Table 3.

The relation of expression of hMSH2, hMLH1, TβRII, E-cadherin, β-catenin, matrix metalloproteinase-7 and tissue inhibitor of metalloproteinase-2 with clinicopathological characteristics of Lynch syndrome and sporadic colorectal carcinoma

Clinicopathological parameter	n	hMSH2	hMLH1	TGFβRII	E-cadherin	Cytomembrane β-catenin	Cytoplasmic β-catenin	MMP-7	TIMP-2
Lynch syndrome	30	7	16	12	26	25	14	14	19
Male	23	4	10	10	21	20	9	12	14
Female	7	3	6	2	5	5	5	2	5
Tumor size
< 4 cm	16	4	8	7	14	13	8	8	10
≥ 4 cm	14	3	8	5	12	12	6	6	9
Position
Right half of colon	18	4	9	7	16	16	9	10	11
Left half of colon	3	1	2	1	3	2	1	1	2
Rectum	9	1	5	4	7	7	4	3	6
Invasion
Inner chorion	21	5	10	11^a	21^a	20^a	7	7	17^a ^c
Outer chorion	9	2	6	1	5	5	7^a	7^a	2^c
Metastasis
No	21	4	11	11^a	21^a	20^a	7	6	18^a ^c
Yes	9	3	5	1	5	5	7^a	8^a	1
Sporadic CRC	30	19	25	22	18	15	24	26	6
Male	20	12^c	17^c	14	11	10	17	18	4
Female	10	7	8	8	7	5	7	8	2
Tumor size
< 4 cm	13	9^c	11^c	9	8	7	11	10	4
≥ 4 cm	17	10^c	14	13	10	8	13	16	2
Position
Right half of colon	14	8^c	11	12	9	9	12	13	3
Left half of colon	5	4	4	3	3	2	3	4	1
Rectum	11	7^c	10	7	6	4	9	9	2
Invasion
Inner chorion	14	7	11	13^a ^c	12^a	10^a	9	10^c	5^a
Outer chorion	16	12^c	14	9^b	6	5	15^a	16^a	1
Metastasis
No	12	7^c	10	12^a ^c	10^a	9^a	7	8^c	5^a
Yes	18	12	15	10^c	8	6	17^a	18^a	1

Compared within the group;

Compared between groups, P < 0.05. CRC: Colorectal carcinoma; TGFβRII: Transforming growth factor-β type II receptor; MMP-7: Matrix metalloproteinase-7.