Table 3.
Diagnostic characteristics of total bilirubin, international normalized ratio and combined criteria on postoperative day (3, 5, 7) in the prediction of liver failure-related death
| Criteria | AUC | 95%CI | Sensitivity | Specificity | P value | Cut-off value |
| POD 3 | ||||||
| TBIL-r1 | 0.686 | 0.642-0.727 | 92.90% | 51.70% | 0.018 | 1.24 |
| INR-r1 | 0.658 | 0.614-0.701 | 64.30% | 64.90% | 0.046 | 0.94 |
| Combination1 | 0.719 | 0.676-0.759 | 64.30% | 74.80% | 0.005 | 0.0337 |
| POD 5 | ||||||
| TBIL-r1 | 0.918 | 0.890-0.941 | 85.70% | 87.50% | 1.0e-7 | 1.68 |
| INR-r1 | 0.719 | 0.677-0.759 | 50.00% | 94.80% | 0.006 | 1.02 |
| Combination1 | 0.951 | 0.927-0.968 | 92.90% | 90.10% | 9.0e-9 | 0.0379 |
| TBIL | 0.810 | 0.772-0.844 | 78.60% | 81.50% | 7.7e-5 | 51.0 |
| INR | 0.708 | 0.665-0.748 | 85.70% | 64.40% | 0.008 | 1.23 |
| Combination2 | 0.829 | 0.792-0.861 | 99.80% | 57.50% | 2.8e-5 | 0.0164 |
| POD 7 | ||||||
| TBIL-r1 | 0.937 | 0.912-0.957 | 85.70% | 91.60% | 2.4e-8 | 1.61 |
| INR-r1 | 0.796 | 0.757-0.831 | 71.40% | 80.00% | 1.5e-4 | 0.91 |
| Combination1 | 0.975 | 0.956-0.987 | 92.90% | 94.40% | 1.4e-9 | 0.0566 |
| TBIL | 0.886 | 0.854-0.913 | 92.90% | 79.10% | 1.0e-6 | 49.5 |
| INR | 0.798 | 0.760-0.833 | 85.70% | 73.30% | 1.4e-4 | 1.22 |
| Combination2 | 0.908 | 0.879-0.933 | 92.90% | 79.70% | 8.7e-7 | 0.0277 |
1
The combination of TBIL-r1 and INR-r1 used the predicted probabilities, which were calculated using logistic regression analysis;
2
The combination of TBIL and INR used the predicted probabilities, which were calculated using logistic regression analysis. AUC: Area under the receiver operating curve; TBIL: Total bilirubin; INR: International normalized ratio; TBIL-r1: The ratio of total bilirubin on postoperative day (POD) X to the value on POD 1; INR-r1: The ratio of international normalized ratio on POD X to the value on POD 1.