Table 2.
Subcortical brain regions.
| Caspase‐3 positive neurons number of cells/mm3 (fold increase from “true” control) | |||||
|---|---|---|---|---|---|
| True (n = 5–7) | ISO (n = 4) | ISO + N2O (n = 6) | ISO + midazolam (n = 3) | ||
| Amygdaloid nuclei | Nucleus medialis | 213 ± 69 | 1017 ± 151* (4.8) | 730 ± 124* (3.4) | 1806 ± 455* (8.5) |
| Nucleus basalis medialis | 221 ± 80 | 966 ± 108* (4.4) | 831 ± 72* | 3160 ± 858* (14.3) | |
| Nucleus lateralis | 187 ± 58 | 523 ± 169* (2.8) | 980 ± 341* (5.2) | 728 ± 169* (3.9) | |
| Nucleus centralis | 72 ± 48 | 285 ± 149 (4) | 726 ± 203 (10.1) | 1399 ± 28* (19.4) | |
| Subiculum | 158 ± 65 | 1162 ± 319* (7.4) | 1343 ± 132* (8.5) | 2502 ± 356* (15.9) | |
| Hippocampus | CA1 | 104 ± 33 | 388 ± 103 (3.7) | 529 ± 149 (5.1) | 1501 ± 172* (14.4) |
| CA2 | 179 ± 29 | 1267 ± 107* (7.1) | 2376 ± 205* (13.3) | 1874 ± 98* (10.5) | |
| CA3 | 72 ± 23 | 788 ± 105* (11) | 1829 ± 113* (25.4) | 1472 ± 39* (20.4) | |
| CA4 | 145 ± 33 | 590 ± 155* (4.1) | 789 ± 116* (5.4) | 645 ± 98* (4.4) | |
| Anterior thalamus | Nucleus lateralis | 269 ± 71 | 349 ± 78 (1.3) | 952 ± 233* (3.5) | 1434 ± 265* (5.3) |
| Nucleus medialis | 195 ± 63 | 515 ± 139 (2.6) | 787 ± 138* (4) | 868 ± 104* (4.5) | |
| Nucleus ventralis | 219 ± 66 | 369 ± 106 (1.7) | 869 ± 191 (4) | 1597 ± 461* (7.3) | |
| Nucleus reticularis | 151 ± 26 | 402 ± 116 (2.7) | 662 ± 165 (4) | 1090 ± 202 (7.2) | |
*
P < 0.001 compared to “true” controls (see text).