Table 1. Baseline characteristics across four groups in RUPP Autism Network Risperidone Trials.
| Risperidone (N=49) | Placebo (N=52) | Risperidone (N=49) | Risperidone + PT (N=75) | |
|---|---|---|---|---|
| Mean Age (SD) | 8.6 (2.97) | 9.1 (2.6) | 7.50 (2.80) | 7.38 (2.21) |
| N (%) | N (%) | N (%) | N (%) | |
| Males | 39 (80) | 43 (83) | 40 (82) | 65 (87) |
| ASD Diagnosis | ||||
| Autistic Disorder | 49 (100%) | 52 (100%) | 32 (65.3) | 49 (65.3) |
| PDD-NOS | 0 | 0 | 13 (26.5) | 22 (29.3) |
| Asperger's | 0 | 0 | 4 (8.2) | 4 (5.3) |
| IQ* | ||||
| ≥ 70 | 11 (23.9) | 6 (13.3) | 23 (46.9) | 46 (63.0) |
| < 70 | 35 (76.1) | 39 (86.7) | 26 (53.1) | 27 (37.0) |
| CGI | ||||
| Moderate | 9 (18) | 9 (17) | 14 (28.6) | 25 (33.3) |
| Marked | 27 (55) | 28 (57) | 19 (38.8) | 33(44.0) |
| Severe | 12 (24) | 12 (24) | 15 (30.6) | 17 (22.7) |
| Extreme | 1 (2) | 0 | 1(2.0) | 0 (0.0) |
| Vineland (standard scores) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) |
| Communication | 45.0 (16.7) | 42.0 (14.3) | 53.2(19.94) | 61.1 (20.95) |
| Socialization | 49.1 (16.6) | 47.4 (10.1) | 53.5 (14.41) | 59.5 (15.01) |
| Daily Living | 40.8 (21.0) | 34.0 (15.6) | 41.1 (19.81 | 50.8 (18.49) |
| ABC | ||||
| Irritability | 26.2 (7.9) | 25.5 (6.6) | 29.7 (6.1) | 29.3 (7.0) |
| Social Withdrawal | 16.4 (8.2) | 16.1 (8.7) | 17.1 (8.5) | 15.2 (9.0) |
| Stereotypy | 10.6 (4.9) | 9.0 (4.4) | 10.6 (5.5) | 7.59 (5.2) |
| Hyperactivity | 31.8 (9.6) | 32.3 (8.5) | 36.1 (6.9) | 35.3 (9.3) |
| Inappropriate Speech | 4.8 (4.1) | 6.5 (3.1) | 6.37 (4.0) | 5.75 (3.4) |
| CSI | ||||
| PDD | 24.3 (6.9) | 23.2 (7.7) | 23.2 (7.0) | 22.0 (7.7) |
| Anxiety | 14.5 (9.7) | 13.8 (7.6) | 14.6 (9.5) | 17.2 (10.3) |
*
IQ missing on 12 subjects; 10 subjects in RUPP 1 and 2 subjects in RUPP 2.