Table 4.

Variations in associations between mental disorders and heart disease by timing of heart disease onset.

Type of Mental Disorders	Mental disorder*Person-year interaction†			Stratified Models‡
				Up to Age 46	Age 47–55	Age 56–66	Age 67+
	OR (95% C.I.)	χ21	[p]	OR (95% C.I.)	OR (95% C.I.)	OR (95% C.I.)	OR (95% C.I.)
Major Depressive Episode/ Dysthymia	0.99* (0.98– 0.99)	14.3*	[0.000]	1.3* (1.0–1.7)	1.3* (1.0–1.8)	1.1 (0.8–1.4)	1.1 (0.8–1.5)
Bipolar Disorder (Broad)	0.98* (0.96– 1.00)	4.8*	[0.029]	1.3 (0.8–2.1)	0.6 (0.3–1.3)	0.7 (0.2–1.9)	0.4 (0.1–1.6)
Generalized Anxiety Disorder	0.98* (0.97– 1.00)	7.1*	[0.008]	1.0 (0.7–1.3)	1.1 (0.7–1.6)	0.9 (0.6–1.3)	0.7 (0.4–1.1)
Alcohol Abuse	0.98* (0.97– 1.00)	6.0*	[0.014]	1.9* (1.3–2.7)	1.2 (0.8–1.7)	0.9 (0.6–1.4)	0.5 (0.2–1.2)

^*OR significant at the 0.05 level, 2-sided test

^†A series of multivariate models were estimated. For example, the model for depression included the dummy variables for all mental disorders plus the cross-product term for depression and person-year, plus the controls specified for earlier models.

^‡The multivariate model was estimated in the four person-year datasets corresponding to quartiles of the heart disease onset distribution. The fourth quartile (67 years +) did not include data from Colombia, Mexico, Peru and Poland as the upper age limit on participants in these countries was 65.