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. 2013 Jul 12;74(3):449–457. doi: 10.1002/ana.23951

Figure 2.

Figure 2

Results in Case 1. (A) Sample section of adaptive deep brain stimulation (aDBS) recordings. Channels are from bottom to top: analogue filtered local field potential (LFP; bipolar contacts 0 and 2), LFP digitally filtered about the beta peak, running average of rectified, beta filtered, amplitude with triggering threshold superimposed, stimulation trigger signal and stimulation (130Hz, 100μS, monopolar contact 1). Boxed area shows a beta burst. Time for this to cross threshold depends on LFP amplitude at onset of beta burst, but thereafter there was only a 30- to 40-millisecond delay to stimulation onset. Note stimulation is ramped, and can be triggered by bursts of beta that are of variable duration, but often last <1 second (see also Table2). (B) LFP power spectrum without DBS. (C) LFP power changes in different stimulation modes. (D) Motor impairment in different stimulation modes. Solid black and interrupted gray lines are unblinded clinical and blinded video scores, respectively. (E) Sections (500 seconds) of rectified beta-filtered LFP amplitude in each stimulation mode. a.u. = arbitrary units; cDBS = continuous DBS; UPDRS = United Parkinson's Disease Rating Scale.