Preoperative Unified Parkinson's Disease Rating Scale motor scores “off” and “on” l-dopa according to genetic subgroupa
| UPDRS score: Mean ± SD | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Off l-dopa | On l-dopa | ||||||||||
| Genetic test results | Tremor | Bradykinesia/rigidity | Axial | Tremor | Bradykinesia/rigidity | Axial | |||||
| Parkin (compound heterozygotes/homozygotes; N = 5) | 6.4 ± 3.8 | 36.4 ± 7.4 | 14.2 ± 4.2 | 1.4 ± 1.7 | 13.0 ± 4.5 | 6.6 ± 2.4 | |||||
| GBA (confirmed mutation; N = 16) | 6.9 ± 5.1 | 31.2 ± 11.0 | 13.1 ± 5.7 | 1.2 ± 1.9 | 12.1 ± 11.0 | 4.7 ± 4.6 | |||||
| LRRK2 (N = 5) | 9.4 ± 2.2 | 40.8 ± 8.8 | 15.2 ± 6.7 | 0 ± 0.0 | 8.3 ± 3.6 | 2.5 ± 2.1 | |||||
| No mutation found (N = 67) | 7.3 ± 5.3 | 29.4 ± 10.3 | 10.8 ± 4.8 | 1.7 ± 3.4 | 10.3 ± 7.4 | 3.6 ± 2.9 | |||||
a
There were no significant differences in the motor phenotype according to genetic subgroup. Tremor was seen in all subgroups, and the proportion of tremor compared with akinesia/rigidity or axial features was similar in each group.
UPDRS, Unified Parkinson's Disease Rating Scale; SD, standard deviation; GBA, glucosidase beta acid; LRRK2, leucine-rich repeat kinase 2.