Table 3.

Adjunctive anti-inflammatory therapies in CAP.

Type of adjunctive therapy	Current status
Macrolide antibiotics	Recommended in current guidelines primarily for antimicrobial activity. The clinical relevance of anti-inflammatory activity remains to be conclusively established
Corticosteroids	Remains controversial and is the subject of several ongoing randomised, prospective, controlled trials
Statins	Show promise, but therapeutic efficacy of initiation at the time of diagnosis of CAP remains to be established
cAMP-elevatory agents	Theoretically promising, although few safe and effective agents currently available; salbutamol found ineffective in the treatment of ALI
NSAIDs	Of questionable value