Table 2.
Locus Information for Associated SNPs | Alcohol Consumption | Alcohol Dependence | Illicit Drugs | Nicotine | Behavioral Disinhibition | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||||||||
SNP | CHR | BP(Build 37.3) | SNP Class | Gene | MA | MAF | Beta | p | Beta | p | Beta | p | Beta | p | Beta | p |
rs1296438 | 1p32.3 | 53,937,177 | Flanking 3’ | GLIS1 | G | .26 | 2.05 | 1.3e-2 | .25 | 2.3e-3 | 8.22 | 1.0e-4 | 5.87 | 7.9e-6 | 1.37 | 6.2e-4 |
rs1298637 | 1p32.3 | 53,958,603 | Flanking 3’ | GLIS1 | A | .26 | 2.11 | 1.1e-2 | .25 | 1.7e-3 | 7.97 | 1.6e-4 | 5.97 | 5.3e-6 | 1.42 | 3.8e-4 |
rs1368882 | 1p32.3 | 55,107,019 | Flanking 5’ | GLIS1 | A | .38 | 1.84 | 1.5e-2 | .27 | 2.9e-4 | 4.90 | 1.2e-2 | 4.46 | 2.1e-4 | 1.75 | 1.9e-6 |
rs10926554 | 1q43 | 241,894,086 | Intron | WDR64 | A | .13 | -2.73 | 1.3e-2 | -.35 | 1.0e-3 | -13.13 | 3.3e-6 | -7.02 | 5.9e-5 | -2.00 | 1.8e-4 |
rs6712333 | 2q37.1 | 231,230,171 | Intron | SP140L | A | .12 | 3.52 | 2.3e-3 | .45 | 6.1e-5 | 9.86 | 8.3e-4 | 8.32 | 5.3e-6 | 1.55 | 5.4e-3 |
rs7620363 | 3p22.3 | 34,013,205 | Intergenic | A | .35 | -2.62 | 7.1e-4 | -.23 | 2.4e-3 | -6.49 | 1.0e-3 | -4.31 | 4.6e-4 | -1.66 | 9.2e-6 | |
rs11918665 | 3q27.3 | 186,213,784 | Flanking 3’ | CRYGS | A | .13 | 3.82 | 5.5e-4 | .29 | 7.0e-3 | 15.03 | 1.1e-7 | 6.20 | 4.2e-4 | 1.98 | 2.2e-4 |
rs1868152 | 3q27.3 | 186,220,063 | Flanking 3’ | CRYGS | A | .12 | 3.81 | 7.0e-4 | .30 | 5.6e-3 | 15.68 | 4.9e-8 | 6.61 | 2.2e-4 | 2.26 | 3.5e-5 |
rs4440177 | 4q32.2 | 163,243,053 | Intergenic | A | .34 | 2.68 | 6.6e-4 | .35 | 6.3e-6 | 8.15 | 5.3e-5 | 4.42 | 4.1e-4 | 1.23 | 1.3e-3 | |
rs13259289 | 8p23.2 | 4,110,032 | Intron | CSMD1 | G | .40 | -2.76 | 2.2e-4 | -.25 | 5.3e-4 | -8.68 | 5.9e-6 | -2.85 | 1.7e-2 | -1.45 | 6.4e-5 |
rs804292 | 8p23.1 | 11,643,915 | 3’ UTR | NEIL2 | G | .23 | -2.88 | 1.1e-3 | -.41 | 1.6e-6 | -9.00 | 6.8e-5 | -6.53 | 3.4e-6 | -1.62 | 1.5e-4 |
rs1793257 | 11q25 | 12,584,119 | Intron | OPCML | A | .04 | 0.75 | 6.9e-1 | .83 | 7.4e-6 | 14.10 | 3.7e-3 | 7.51 | 1.3e-2 | 3.23 | 4.6e-4 |
rs4788985 | 17q25.2 | 75,313,335 | Flanking 5’ | SEPT9 | G | .49 | 2.46 | 7.8e-4 | .18 | 1.2e-2 | 8.35 | 8.9e-6 | 4.37 | 1.8e-4 | 1.04 | 3.5e-3 |