Table 3.

SNPs showing a SNP by Generation interaction effect at p < E-03 for at least two clinical phenotypes.

	rs10037670	rs2380220	rs2380222	rs7968335
CHR	5q33.2	6q16.1	6q16.1	12q21.31
Base Position (Build 37.3)	153,791,683	96,074,133	96,082,116	83,748,272
SNP Class	Flanking 3’ UTR	Intergenic	Intergenic	Flanking 3’ UTR
Gene	GALNT10			SLC6a15
Minor Allele	G	A	G	A
MAF	.208	.159	.160	.410
Alcohol Consumption
Interaction p value	2.9E-03	4.3E-05	5.2E-05	6.5E-04
Parent Beta	-0.894	-1.179	-1.207	0.233
Parent Beta p	2.7E-02	8.1E-03	6.6E-03	4.8E-01
Offspring Beta	2.005	3.227	3.143	-2.484
Offspring Beta p	3.0E-02	1.6E-03	2.1E-03	1.1E-03
Alcohol Dependence
Interaction p value	4.3E-03	4.4E-06	5.0E-06	7.3E-06
Parent Beta	-0.184	-0.249	-0.255	0.196
Parent Beta p	4.1E-02	1.2E-02	9.5E-03	7.2E-03
Offspring Beta	0.164	0.370	0.359	-0.251
Offspring Beta p	6.8E-02	3.2E-04	3.2E-04	6.9E-04
Illicit Drugs
Interaction p value	3.8E-06	3.7E-04	3.0E-04	1.0E-01
Parent Beta	-5.250	-3.737	-3.830	1.381
Parent Beta p	6.6E-03	8.0E-02	7.2E-02	3.8E-01
Offspring Beta	8.206	7.767	7.782	-2.499
Offspring Beta p	5.2E-04	3.1E-03	2.8E-03	2.0E-01
Nicotine
Interaction p value	3.5E-04	4.6E-04	2.5E-04	2.0E-01
Parent Beta	-2.089	-2.445	-2.722	1.3E-02
Parent Beta p	1.8E-01	1.6E-01	1.2E-01	0.613
Offspring Beta	5.217	5.473	5.525	6.3E-01
Offspring Beta p	3.9E-04	7.7E-04	6.6E-04	-3.551
Behavioral Disinhibition	5.7E-05	3.6E-04	3.3E-04	1.9E-04
Interaction p value	-0.397	-0.613	-0.638	0.479
Parent Beta	1.6E-01	4.7E-02	3.8E-02	3.6E-02
Parent Beta p	1.601	1.349	1.330	-1.040
Offspring Beta	3.6E-04	6.7E-03	7.4E-03	4.8E-03
Offspring Beta p