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. 2013 Dec 6;86(1):443–452. doi: 10.1021/ac4023378

Table 2. Peptides with Differential Abundance for Both Spectral Count and Spectral Index.

  peptide
 NSa
 spectral count
 spectral index
UniProt Accnb locationc sequence and PTM D N D/Nd SEe p-value aPVf D/N SE p-value aPV
P49192 CARTPT[37–54] ALDIYSAVDDASHEKELP 9 9 0.56 0.07 1.66 × 10–06 1.22 × 10–21 0.59 0.03 2.85 × 10–05 2.19 × 10–20
P49192 CARTPT[37–54] ALDIYSAVDDAS[phos]HEKELP 9 9 0.62 0.08 1.80 × 10–04 1.46 × 10–06 0.60 0.06 1.97 × 10–03 6.39 × 10–06
P49192 CARTPT[60–79] APGAVLQIEALQEVLKKLKS 3 4 11.13 5.74 3.03 × 10–06 1.53 × 10–40 11.25 2.04 4.59 × 10–05 1.10 × 10–38
P11240 COX5A[56–66] FNKPDIDAWEL 6 7 4.89 1.51 2.60 × 10–07 1.13 × 10–09 3.15 0.59 5.23 × 10–06 8.13 × 10–09
P14200 MCH[32–55] NVEDDIVFNTFRMGKAFQKEDTAE 6 9 0.59 0.09 7.41 × 10–04 2.73 × 10–03 0.68 0.09 6.38 × 10–03 8.05 × 10–03
P30904 MIF[11–27] PRASVPEGFLSELTQQL 6 8 2.23 0.48 1.64 × 10–04 2.99 × 10–10 3.05 0.54 1.88 × 10–03 2.38 × 10–09
P19804 NDKB[2–16] [acetyl]ANLERTFIAIKPDGV 9 4 7.88 3.52 3.69 × 10–06 2.44 × 10–07 2.80 0.56 5.23 × 10–05 1.28 × 10–06
Q9QXU9 PCSK1[113–143] WGSPRASDPPLAPDDDPDAPAAQLARALLRA 6 3 0.25 0.09 2.14 × 10–04 2.37 × 10–92 0.23 0.02 2.24 × 10–03 5.10 × 10–90
Q9QXU9 PCSK1[221–242] (PEN) AVDQDLGPEVPPENVLGALLRV 9 9 0.69 0.04 2.19 × 10–13 7.42 × 10–29 0.43 0.03 5.28 × 10–11 1.59 × 10–27
P06300 PDYN[211–218] PKLKWDNQ 7 9 0.22 0.06 1.44 × 10–07 5.26 × 10–09 0.36 0.06 3.46 × 10–06 3.53 × 10–08
P31044 PEBP1[170–187] [pyro]QAEWDDSVPKLHDQLAGK 9 6 2.77 0.67 2.44 × 10–05 5.80 × 10–07 1.69 0.18 2.94 × 10–04 2.71 × 10–06
P31044 PEBP1[93–120] KGNDISSGTVLSEYVGSGPPKDTGLHRY 6 5 2.37 0.59 5.52 × 10–04 2.22 × 10–05 2.70 0.63 5.12 × 10–03 8.69 × 10–05
P04094 PENK[263–269] (Met-enkephalin-Arg-Phe) YGGFMRF 4 9 0.07 0.04 1.23 × 10–07 5.54 × 10–19 0.10 0.03 3.30 × 10–06 7.44 × 10–18
Q9R063 PRDX5[204–213] SLAPNILSQL 9 7 5.22 1.52 1.44 × 10–08 1.39 × 10–06 4.13 1.21 6.93 × 10–07 6.22 × 10–06
Q9R063 PRDX5[54–67] PIKVGDTIPSVEVF 6 8 3.84 1.11 3.05 × 10–06 1.65 × 10–32 2.72 0.23 4.59 × 10–05 5.07 × 10–31
O35314 SCG1[597–611] [pyro]QYDDGVAELDQLLHY 9 9 0.63 0.06 3.98 × 10–07 2.34 × 10–06 0.58 0.07 7.38 × 10–06 1.01 × 10–05
P10362 SCG2[495–517] PYDNLNDKDQELGEYLARMLVKY 3 4 5.62 1.81 8.59 × 10–08 4.64 × 10–13 5.98 1.48 2.59 × 10–06 5.25 × 10–12
P10362 SCG2[529–554] VPSPGSSEDDLQEEEQLEQAIKEHLG 9 6 3.22 0.70 8.24 × 10–08 2.34 × 10–04 2.34 0.54 2.59 × 10–06 8.00 × 10–04
P10362 SCG2[571–583] IPAGSLKNEDTPN 6 6 4.52 0.98 4.40 × 10–12 1.90 × 10–08 15.12 7.30 3.53 × 10–10 1.20 × 10–07
Q6PDU1 SFRS2[2–21] [acetyl]SYGRPPPDVEGMTSLKVDNL 3 8 0.10 0.05 7.28 × 10–06 3.58 × 10–19 0.18 0.03 9.75 × 10–05 5.14 × 10–18
P06767 TKN1[72–94] DADSSIEKQVALLKALYGHGQIS 9 9 0.66 0.07 2.15 × 10–05 3.85 × 10–38 0.47 0.03 2.72 × 10–04 2.07 × 10–36
P08435 TKNK[95–115] NSQPDTPADVVEENTPSFGVL 8 9 0.45 0.07 2.21 × 10–07 3.10 × 10–05 0.41 0.09 4.84 × 10–06 1.19 × 10–04
Q5PPN5 TPPP3[2–17] [acetyl]AASTDIAGLEESFRKF 9 9 2.97 0.46 1.37 × 10–12 4.71 × 10–08 3.15 0.66 1.66 × 10–10 2.81 × 10–07
P20156 VGF[285–309] (neuroendocrine regulatory peptide-1) LEGSFLGGSEAGERLLQQGLAQVEA 4 9 0.13 0.04 5.72 × 10–11 2.22 × 10–10 0.30 0.06 3.45 × 10–09 1.84 × 10–09
a

Number of daytime (D) and nighttime (N) samples where the peptide was detected.

b

Uniprot accession number.

c

Peptide location within in the prohormone : CARTPT, CART prepropeptide; COX5A, cytochrome c oxidase, subunit Va; MCH, pro-melanin-concentrating hormone; MIF, macrophage migration inhibitory factor (glycosylation-inhibiting factor); NDKB, NME/NM23 nucleoside diphosphate kinase 2; PCSK1N, proprotein convertase subtilisin/kexin type 1 inhibitor; PDYN, prodynorphin; PEBP1, phosphatidylethanolamine binding protein 1; PENK, proenkephalin; PRDX5, peroxiredoxin 5; SCG1, chromogranin B (secretogranin 1); SCG2, secretogranin II; SFRS2, serine/arginine-rich splicing factor 2; TKN1, tachykinin, precursor 1; TKNK, tachykinin 3; TPPP3, tubulin polymerization-promoting protein family member 3; VGF, VGF nerve growth factor inducible; and peptide name in parentheses if known.

d

Ratio of peptide abundance at daytime compared to nighttime.

e

Standard error of the peptide abundance ratio at daytime compared to nighttime.

f

False discovery rate adjusted p-value.