Table 2.
Results of genotyping and molecular drug susceptibility testing for 1,242 pulmonary tuberculosis patients with smear, culture and positive tuberculosis, Iran*
| Province | Spoligotype patterns | Susceptibility patterns | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAS | H | T | Beijing | Manu | U | LAM | Bovis | EAI | X | Orphan | Susceptible | MDR | RMR | INHR | Total | |
| Tehran | 107 | 85 | 47 | 35 | 14 | 6 | 2 | 4 | 1 | 23 | 246 | 32 | 26 | 20 | 324 | |
| Sistan and Balouchastan | 59 | 65 | 16 | 3 | 2 | 2 | – | – | – | 1 | 17 | 146 | 1 | 10 | 8 | 165 |
| Khouzestan | 67 | 7 | 13 | 5 | 2 | 6 | 7 | 1 | 2 | – | 9 | 103 | 6 | 3 | 7 | 119 |
| Khorasan | 34 | 42 | 19 | 12 | 3 | 2 | 1 | – | – | – | 4 | 96 | 2 | 9 | 10 | 117 |
| Ardebil | 16 | 10 | 29 | 7 | 1 | – | – | 2 | – | – | – | 55 | 4 | 4 | 2 | 65 |
| Qom | 18 | 20 | 8 | 10 | – | – | – | 2 | – | – | 3 | 51 | 4 | 3 | 3 | 61 |
| Golestan | 23 | 8 | 8 | 6 | – | – | – | – | – | – | 2 | 40 | 2 | 2 | 3 | 47 |
| Esfahan | 17 | 2 | 12 | 6 | – | – | 2 | – | – | – | 3 | 32 | 2 | 3 | 5 | 42 |
| Gilan | 18 | 13 | 2 | – | – | – | 1 | – | – | – | 5 | 31 | 3 | 2 | 1 | 39 |
| Fars | 16 | 14 | 1 | 5 | – | – | 1 | – | – | – | 3 | 28 | 5 | 5 | 2 | 40 |
| Hormozgan | 19 | 8 | 4 | 5 | 1 | – | 1 | – | – | – | – | 29 | 3 | 3 | 3 | 38 |
| Mazandarn | 4 | 6 | 13 | 1 | – | – | – | – | – | 1 | 1 | 23 | 1 | 1 | 1 | 26 |
| Semnan | 7 | 8 | 5 | 1 | – | – | – | – | – | – | – | 21 | 0 | 0 | 0 | 21 |
| Lorestan | 15 | 7 | 2 | – | – | – | – | – | – | – | – | 19 | 0 | 5 | 0 | 24 |
| Hamadan | 7 | 5 | 3 | 1 | 1 | – | – | – | – | – | 4 | 18 | 0 | 2 | 1 | 21 |
| Kerman | 10 | 8 | 2 | – | – | 1 | – | – | – | – | 3 | 17 | 3 | 3 | 1 | 24 |
| Kurdistan | 4 | 9 | 3 | – | – | – | – | – | – | – | – | 14 | 0 | 0 | 2 | 16 |
| Kermanshah | 9 | 2 | 4 | 1 | – | – | – | – | – | – | – | 12 | 1 | 2 | 1 | 16 |
| Markazei | 9 | 4 | 3 | – | – | – | – | – | – | – | 7 | 2 | 3 | 3 | 15 | |
| Yazd | 6 | 2 | 4 | – | – | – | – | – | – | – | – | 11 | 0 | 1 | 0 | 12 |
| Qazvin | 6 | 2 | – | – | 1 | – | – | 1 | – | – | – | 7 | 2 | 0 | 1 | 10 |
| Total | 471 | 326 | 195 | 101 | 25 | 17 | 15 | 10 | 3 | 2 | 77 | 1,007 | 73 | 92 | 70 | 1242 |
| % | 37.9 | 26 | 16 | 81.1 | 2 | 13 | 1.2 | 0.8 | 0.2 | 0.16 | 61.1 | 81.0 | 5.8 | 7.4 | 5.63 | |
*
There was no statistical difference between spoligotypes of susceptible and rifampin-monoresistant tuberculosis isolates. The CAS and H lineages are the most frequent superfamilies in Iran. MDR = multidrug resistant; RMR = rifampin monoresistant; INHR = isoniazid resistant.