Table 2.
Body composition variables
| Expansion cohort (N=26) | Escalation cohorts (N=22) | All patients (N=48) | |
|---|---|---|---|
|
| |||
| Average (SEM) | Average (SEM) | Average (SEM) | |
| Female (n=29) | |||
| Weight (kg) | 72.8 (4.1) | 65.5 (3.8) | 69.5 (2.9) |
| Skeletal muscle area at L3 (cm2) | 108.2 (5.1) | 109.6 (5.3) | 108.8 (3.6) |
| Intramuscular adipose area at L3 (cm2) | 13.5 (1.9) | 11.0 (2.2) | 12.4 (1.4) |
| Visceral adipose area at L3 (cm2) | 84.9 (17.6) | 67.0 (13.9) | 76.9 (11.5) |
| Subcutaneous adipose area at L3 (cm2) | 184.0 (27.4) | 173.7 (32.2) | 179.4 (20.5) |
| BMI (kg/m2) | 26.5 (1.4) | 24.7 (1.6) | 25.7 (1.0) |
| Muscle index (cm2/m2) | 39.4 (1.6) | 41.0 (1.9) | 40.1 (1.2) |
| Total estimated lean body mass (kg) | 38.5 (1.5) | 38.9 (1.6) | 38.7 (1.1) |
| Total estimated fat body mass (kg) | 18.9 (1.2) | 18.5 (1.4) | 18.7 (0.9) |
| Sarcopenic [n (%)] | 4 (30%) | 7 (40%) | 11 (38%) |
| BMI categories [n (%)] | |||
| <18.5 kg/m2 | 0 (0%) | 2 (15%) | 2 (7%) |
| 18.5–24.9 kg/m2 | 7 (44%) | 4 (31%) | 11 (38%) |
| 25–29.9 kg/m2 | 5 (31%) | 5 (39%) | 10 (34%) |
| ≥30 kg/m2 | 4 (25%) | 2 (15%) | 6 (21%) |
| Male (n=19) | |||
| Weight (kg) | 86.7 (5.6) | 92.4 (8.1) | 89.4 (4.7) |
| Skeletal muscle area at L3 (cm2) | 167.8 (10.7) | 168.9 (9.4) | 168.3 (7.0) |
| Intramuscular adipose area at L3 (cm2) | 14.0 (3.6) | 13.3 (2.7) | 13.7 (2.2) |
| Visceral adipose area at L3 (cm2) | 124.8 (43.4) | 182.6 (31.5) | 152.2 (27.4) |
| Subcutaneous adipose area at L3 (cm2) | 159.7 (26.8) | 230.6 (49.6) | 193.3 (27.9) |
| BMI (kg/m2) | 26.8 (1.5) | 29.2 (1.8) | 27.9 (1.2) |
| Muscle index (cm2/m2) | 51.9 (3.1) | 54.1 (2.9) | 52.9 (2.1) |
| Total estimated lean body mass (kg) | 56.4 (3.2) | 56.7 (2.8) | 56.6 (2.1) |
| Total estimated fat body mass (kg) | 17.9 (1.1) | 20.9 (2.1) | 19.3 (1.2) |
| Sarcopenic [n (%)] | 5 (50%) | 5 (55%) | 10 (53%) |
| BMI categories [n (%)] | |||
| <18.5 kg/m2 | 0 (0%) | 0 (0%) | 0 (0%) |
| 18.5–24.9 kg/m2 | 4 (40%) | 1 (11%) | 5 (26%) |
| 25–29.9 kg/m2 | 3 (30%) | 4 (44%) | 7 (37%) |
| ≥30 kg/m2 | 3 (30%) | 4 (44%) | 7 (37%) |