Number of patients |
233 |
Number of centers |
83 |
Age, median(range), years |
55 (19 – 79) |
18–40 |
12 (5) |
41–60 |
157 (67) |
>60 |
64 (27) |
Gender |
|
Male |
151 (65) |
Female |
82 (35) |
Karnofsky score |
|
<90% |
84 (36) |
90–100% |
135 (58) |
Missing |
14 (6) |
Time from diagnosis to transplant (range), months |
15 (2 – 305) |
Constitutional symptoms prior to HCT |
|
No |
182 (78) |
Yes |
42 (18) |
Missing |
9 (4) |
Circulating blasts in blood at HCT |
|
Absent |
132 (57) |
≥1% |
101 (43) |
Spleen status at transplant |
|
Spleen not palpable |
52 (22) |
Splenomegaly |
113 (48) |
Splenectomy |
59 (25) |
Missing |
9 (4) |
Cytogenetics prior to HCT |
|
Not evaluable/missing |
84(36) |
Normal Karyotype |
89 (38) |
Abnormal |
66 (28) |
Unfavorable |
30(13) |
Other abnormalities |
30 (13) |
Hemoglobin at HCT |
|
<100g/L |
148(64) |
≥100g/L |
85 (36) |
Platelet count at transplant (range), × 109/L |
121 (5 – 1835) |
Platelet count prior to transplant |
|
<100 × 109/L |
94 (40) |
≥100 × 109/L |
116 (50) |
Missing |
23 (10) |
WBC count at transplant (range), × 109/L |
6 (<1 – 431) |
DIPSS at transplant |
|
Low risk |
27 (12) |
Int-1 |
114 (49) |
Int-2 |
86 (37) |
High-risk |
3 (1) |
Missing |
3 (1) |
Graft type |
|
Bone marrow |
28 (12) |
Peripheral blood |
205 (88) |
Donor type |
|
HLA-identical sibling |
79 (34) |
Well-matched URD |
104 (45) |
Partially matched URD |
40 (17) |
Mismatched URD |
10 (4) |
D-R CMV status |
|
+/+ |
72 (31) |
+/− |
26 (11) |
−/+ |
55 (24) |
−/− |
60 (26) |
Missing |
20 (9) |
Conditioning regimen |
|
FluTBI-based |
51 (22) |
FluMel-based |
65 (28) |
FluBu-based |
89 (38) |
Others |
28 (12) |
ATG or alemtuzumab use |
|
ATG |
110 (47) |
Alemtuzumab |
13 (6) |
GVHD prophylaxis |
|
Tarcrolimus-based |
105 (45) |
Cyclosporine-based |
124 (53) |
Other GVHD prophylaxis |
4 (2) |
Year of transplant |
|
1997–2001 |
26 (11) |
2002–2006 |
116 (50) |
2007–2010 |
91 (39) |
Median follow-up of survivors, range, months |
50 (3 – 134) |