Table 3.
Multivariate analysis for aGVHD, cGVHD, Relapse/Progression, NRM, PFS and Overall Survival.
| N | RR | p-value | 95% CI | Overall p-value | |
|---|---|---|---|---|---|
|
Grade 2–4 acute GVHD
| |||||
| Donor type | 0.02 | ||||
| HLA-identical sibling | 79 | 1 | |||
| Well-matched URD | 104 | 1.98 | 0.006 | 1.22–3.22 | |
| Partially matched/mismatched URD | 50 | 1.52 | 0.18 | 0.83–2.80 | |
| Contrast | |||||
| Well-matched URD vs. Partially matched/mismatched URD | 1.30 | 0.33 | 0.76–2.23 | ||
|
Chronic GVHD
| |||||
| Donor type | 0.33 | ||||
| HLA-identical sibling | 79 | 1 | |||
| Well-matched URD | 104 | 0.81 | 0.35 | 0.51–1.26 | |
| Partially matched/mismatched URD | 50 | 1.21 | 0.49 | 0.67–2.10 | |
|
Relapse/Progression
| |||||
| DIPSS | |||||
| Low/Intermediate-1 | 141 | 1 | 0.04 | ||
| Intermediate-2/high | 89 | 0.65 | 0.04 | 0.42–0.99 | |
|
NRM
| |||||
| DIPSS | |||||
| Low/Intermediate-1 | 141 | 1 | 0.07 | ||
| Intermediate-2/high | 89 | 1.70 | 0.07 | 0.96–3.01 | |
| Donor type | |||||
| HLA-identical sibling | 79 | 1 | < 0.001 | ||
| Well-matched URD | 104 | 3.92 | 0.006 | 1.50–10.33 | |
| Partially matched/mismatched URD | 50 | 9.37 | < 0.001 | 3.49–25.17 | |
| Contrast | |||||
| Well-matched URD vs. Partially matched/mismatched URD | 0.42 | 0.005 | 0.23–0.77 | ||
|
PFS
| |||||
| DIPSS | |||||
| Low/Intermediate-1 | 141 | 1 | 0.55 | ||
| Intermediate-2/high | 89 | 0.90 | 0.55 | 0.65–1.26 | |
| Donor type | 0.03 | ||||
| HLA-identical sibling | 79 | 1 | |||
| Well-matched URD | 104 | 1.17 | 0.42 | 0.80–1.69 | |
| Partially matched/mismatched URD | 50 | 1.75 | 0.01 | 1.14–2.68 | |
| Contrast | |||||
| Well-matched URD vs. Partially matched/mismatched URD | 0.67 | 0.05 | 0.45–0.99 | ||
|
Overall Survival
| |||||
| DIPSS | |||||
| Low/Intermediate-1 | 141 | 1 | 0.10 | ||
| Intermediate-2/high | 89 | 1.37 | 0.10 | 0.95–1.98 | |
| Donor type | |||||
| HLA-identical sibling | 79 | 1 | 0.002 | ||
| Well-matched URD | 104 | 1.57 | 0.05 | 1.01–2.46 | |
| Partially matched/mismatched URD | 50 | 2.48 | 0.0003 | 1.51–4.04 | |
| Conditioning regimen | |||||
| FluTBI-based | 51 | 1 | 0.14 | ||
| FluMel-based | 65 | 0.71 | 0.23 | 0.41–1.23 | |
| FluBu-based | 89 | 1.13 | 0.63 | 0.70–1.82 | |
| Others | 28 | 1.41 | 0.28 | 0.76–2.62 | |
| Contrast | |||||
| FluMel-based vs. FluBu-based | 0.63 | 0.06 | 0.39–1.02 | ||
| FluMel-based vs. Others | 0.55 | 0.03 | 0.27–0.95 | ||
| FluBu-based vs. Others | 0.80 | 0.44 | 0.46–1.41 | ||
| Well-matched URD vs. Partially matched/mismatched URD | 0.64 | 0.04 | 0.41–0.98 | ||