Table 3.
Unit | Phase 1 median | Phase 1 IQI | T0 median | T1 median | ΔT0 T1 | P value | |
---|---|---|---|---|---|---|---|
PCV | % | — | — | 43 | 44 | No | 0.23 |
TP-R | g/dl | 8.2 | 7.6–8.4 | 8.0 | 8.5 | Yes | <0.01 |
TP-B | g/dl | 8.5 | 8.2–9.1 | 8.3 | 8.7 | No | 0.08 |
BUN | mg/dl | 8.0 | 6.0–9.0 | 8.0 | 9.5 | Yes | <0.01 |
Creatinine | mg/dl | 1.7 | 1.48–1.80 | 1.6 | 1.5 | No | 0.06 |
FPO | mOsm/kg | 262 | 257–269 | 259 | 275 | Yes | <0.01 |
SFO | mOsm/kg | 267 | 262–269 | 267 | 276 | No | 0.06 |
Phase 1 (n = 21) median and interquartile intervals (IQI) are shown for reader reference. Results from the phase 2 water deprivation test (n = 16) are shown as T0 (initial blood sample) and T1 (second blood sample); Δ = significant change; P values correspond to Wilcoxon signed-rank test results for paired T0 and T1 values. PCV = packed cell volume (not measured in phase 1); TP-R = total protein measured by refractometer; TP-B = total protein measured by biuret method; BUN = blood urea nitrogen; FPO = freezing point osmometer; SFO = simple formula osmolality (calculated). The average time of water deprivation was 16 hr 34 min; “No” and “Yes” indicate whether significant change occurred.