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48-chamber microfluidic chip for single cell sorting and whole-genome amplification. (A) Design of 48x_v4 device with key ports marked. (B) Photograph of 48-chamber device with corresponding ports marked. (C) Inset showing detail of two reaction chambers in the 48x_v4 device. (D) Cross-sectional schematic corresponding to part (C) indicating the trapping of a cell in the (upper) flow layer and the actuation of valves by pressurization of channels in the (lower) control layer.
