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Efflux of cholesterol and phospholipids from cells to HDL. Phospholipids and cholesterol are exported from cell membranes via ABCA1 to lipid-free or lipid-poor apolipoproteins, generating discoidal HDL that accepts cholesterol from ABCA1, ABCG1, and SR-B1. The cholesterol in discoidal HDL is esterified by LCAT, which generates spherical HDL that accepts cholesterol from ABCG1 and SR-B1.
