TABLE 3.

Plasma 7-KC mean values, range, and P value in healthy subjects, ASMase-deficient NPD, ASMase-deficient NPD heterozygotes, and other LSD patients

	NC	NPA/B	NPA/B-h	NPC	GD	MPSII	GSDII	MLD/KD
n	314	38	8	7	34	38	19	21
Mean and range (ng/ml)	5.2 (ND–23)	245 (101–976)	3.7 (ND–6.1)	279 (32–603)	6.7 (1.5–19)	6.4 (ND–20)	6.3 (ND–20)	3.7 (1–7.9)
P	<0.001a	NA	<0.001a	0.849a	<0.001a	<0.001a	<0.001a	<0.001a

NC, healthy subjects; NPA/B, ASMase-deficient NPD; NPA/B-h, ASMase-deficient NPD heterozygote; NA, not applicable; ND, not detectable.

^aComparison versus NPA/B.