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Clodronate-liposome treatments preserve tissue integrity, evaluate by H&E tissue staining of (A) an isograft and (B–D) three allografts hearts. Untreated isograft and allograft hearts on POD 7 are shown in (A) and (B); (C) a clodronate-liposome treated allograft on POD 7, which reveals decreased damage to the tissue of the graft compared to the untreated allograft on the same day (B); (D) a clodronate-liposome treated allograft on POD 9.
