Figure 10.

(A) Coefficient of variation (CV), calculated as the standard deviation divided by the mean, as a measurement of variability of intima fractional thickness, media fractional thickness, and adventitia fractional thickness per slide in diseased patients (n = 62). (B) CV of profiles of plexiform lesions per slide in patients with plexiform lesions (n = 56). (C) Distribution of profiles of plexiform lesions per slide in idiopathic PAH (IPAH)-like pattern, each column on the x axis representing one patient (n = 48). Each column projecting from the x axis represents one individual patient; the respective y-dots represents the count of plexiform lesion profiles (i.e., outlines) in each of the 12 slides examined in each patient (P = not significant for all).