Table 2.

Early life body size and breast cancer risk by menopausal status in AA women, Women’s Circle of Health Study.

	Pre-menopausal AA women (n=953)					Post-menopausal AA women (n=984)
	Cases/Controls	OR1	95% CI	OR2	95% CI	Cases/Controls	OR1	95% CI	OR2	95% CI
Relative height at 7 or 8*a
Shortest/much shorter	34/34	1.29	0.76–2.20	1.20	0.70–2.07	53/34	1.56	0.96–2.53	1.68	1.02–2.74
Somewhat shorter	46/62	0.92	0.59–1.44	0.85	0.53–1.37	52/61	0.83	0.54–1.28	0.92	0.59–1.43
About the same	248/276	REF		REF		277/264	REF		REF
Somewhat taller	65/51	1.52	0.99–2.32	1.43	0.93–2.22	63/62	1.02	0.68–1.54	1.07	0.70–1.63
Tallest/much taller	77/59	1.44	0.96–2.15	1.39	0.92–2.10	61/55	1.17	0.77–1.80	1.16	0.75–1.79
Relative height at menarche*a
Shortest/much shorter	31/30	1.15	0.66–2.00	1.14	0.65–2.00	42/30	1.42	0.84–2.40	1.51	0.89–2.57
Somewhat shorter	43/62	0.83	0.53–1.31	0.84	0.52–1.34	59/56	1.08	0.70–1.65	1.18	0.76–1.82
About the same	249/268	REF		REF		279/267	REF		REF
Somewhat taller	71/61	1.34	0.89–2.00	1.36	0.90–2.06	63/74	0.89	0.60–1.32	0.91	0.61–1.37
Tallest/much taller	75/60	1.33	0.89–1.99	1.26	0.83–1.91	64/48	1.38	0.89–2.12	1.36	0.87–2.11
Relative height at 15 or 16*a
Shortest/much shorter	31/28	1.27	0.72–2.24	1.24	0.70–2.21	37/28	1.31	0.76–2.25	1.44	0.83–2.51
Somewhat shorter	51/72	0.84	0.56–1.28	0.87	0.57–1.34	61/65	1.05	0.70–1.57	1.16	0.77–1.76
About the same	271/284	REF		REF		304/282	REF		REF
Somewhat taller	61/57	1.26	0.83–1.92	1.21	0.79–1.87	52/63	0.85	0.56–1.31	0.87	0.56–1.36
Tallest/much taller	56/41	1.37	0.86–2.17	1.25	0.78–2.02	53/38	1.43	0.89–2.29	1.40	0.86–2.26
Relative weight at 7 or 8*a
Thinnest/much thinner	82/71	1.24	0.84–1.85	1.08	0.71–1.65	83/74	1.13	0.77–1.66	1.04	0.69–1.55
Somewhat thinner	122/104	1.22	0.87–1.72	1.15	0.81–1.65	122/85	1.50	1.06–2.13	1.44	1.01–2.07
About the same	195/207	REF		REF		231/234	REF		REF
Somewhat heavier	51/82	0.74	0.48–1.12	0.75	0.48–1.17	56/61	0.87	0.56–1.34	0.90	0.57–1.44
Heaviest/much heavier	20/18	1.25	0.62–2.52	1.40	0.67–2.92	12/22	0.52	0.24–1.11	0.54	0.23–1.29
Relative weight at menarche*a
Thinnest/much thinner	74/59	1.27	0.84–1.92	1.22	0.79–1.88	77/70	1.06	0.71–1.57	0.97	0.64–1.46
Somewhat thinner	107/91	1.12	0.78–1.59	1.02	0.70–1.48	110/83	1.29	0.91–1.85	1.17	0.81–1.69
About the same	212/214	REF		REF		249/227	REF		REF
Somewhat heavier	63/100	0.70	0.47–1.03	0.71	0.47–1.08	58/71	0.85	0.56–1.29	0.85	0.54–1.32
Heaviest/much heavier	14/18	0.86	0.40–1.83	0.89	0.39–2.00	11/25	0.40	0.18–0.86	0.45	0.20–1.02
Relative weight at 15 or 16*a
Thinnest/much thinner	64/54	1.19	0.78–1.83	1.18	0.75–1.86	68/57	1.20	0.79–1.82	1.12	0.72–1.73
Somewhat thinner	96/79	1.19	0.82–1.73	1.14	0.77–1.68	102/76	1.39	0.97–2.00	1.31	0.90–1.91
About the same	231/236	REF		REF		268/253	REF		REF
Somewhat heavier	65/91	0.77	0.52–1.13	0.79	0.52–1.20	58/66	0.94	0.62–1.42	0.93	0.59–1.48
Heaviest/much heavier	14/22	0.63	0.30–1.30	0.62	0.28–1.39	10/24	0.42	0.19–0.92	0.49	0.20–1.20
BMI at age 20 yrs.b
<25	347/340	REF		REF		392/365	REF		REF
25–29.9	64/75	0.89	0.61–1.31	1.02	0.67–1.56	52/64	0.87	0.57–1.31	1.01	0.65–1.58
≥30	23/47	0.65	0.37–1.12	0.77	0.42–1.40	17/26	0.65	0.34–1.25	0.88	0.43–1.81
p for trend			0.12		0.52			0.16		0.82
Weight gain since age 20, kgc
Q 1 (≤13.82)	114/130	REF		REF		75/84	REF		REF
Q 2 (13.83–23.72)	118/111	1.15	0.78–1.68	1.27	0.86–1.89	115/106	1.30	0.84–2.00	1.35	0.87–2.10
Q 3 (23.73–34.56)	93/102	0.93	0.62–1.38	1.15	0.73–1.82	110/112	1.20	0.77–1.85	1.29	0.80–2.09
Q 4 (>34.56)	82/91	0.96	0.63–1.47	1.49	0.81–2.73	139/125	1.22	0.80–1.86	1.42	0.80–2.53
p for trend			0.63		0.27			0.60		0.34

^*compared to peers

OR1: Adjusted for age, ethnicity (Hispanic/non-Hispanic), country of origin, education, family history of breast cancer, history of benign breast disease, age at menarche, age at menopause (for postmenopausal women), parity, breastfeeding status, age at first birth, HRT use, oral contraceptive use.

OR2:

^afurther adjusted for BMI at age 20;

^bfurther adjusted for height and weight at menarche;

^cfurther adjusted for current BMI