Table 3.

Early life body size and breast cancer risk by menopausal status in EA women, Women’s Circle of Health Study.

	Pre-menopausal EA women (n=794)					Post-menopausal EA women (n=693)
	Cases/Controls	OR	95% CI	OR2	95% CI	Cases/Controls	OR	95% CI	OR	95% CI
Relative height at 7 or 8*a
Shortest/much shorter	41/56	0.65	0.40–1.06	0.63	0.38–1.04	35/36	1.01	0.57–1.78	1.00	0.56–1.77
Somewhat shorter	51/52	0.93	0.58–1.49	0.90	0.56–1.46	42/43	0.92	0.54–1.57	0.91	0.53–1.56
About the same	170/151	REF		REF		180/145	REF		REF
Somewhat taller	76/70	0.98	0.64–1.48	1.00	0.65–1.52	65/49	1.34	0.83–2.17	1.32	0.81–2.15
Tallest/much taller	62/64	0.85	0.55–1.32	0.82	0.52–1.30	48/48	1.00	0.61–1.67	1.02	0.61–1.71
Relative height at menarche*a
Shortest/much shorter	26/41	0.57	0.32–1.01	0.55	0.31–0.98	27/25	1.15	0.61–2.18	1.24	0.65–2.38
Somewhat shorter	46/62	0.70	0.44–1.10	0.66	0.41–1.06	54/49	1.34	0.81–2.20	1.37	0.83–2.25
About the same	184/160	REF		REF		176/152	REF		REF
Somewhat taller	77/71	0.96	0.64–1.45	0.96	0.63–1.45	64/45	1.41	0.86–2.29	1.38	0.84–2.27
Tallest/much taller	65/59	0.96	0.62–1.50	0.93	0.59–1.47	50/50	1.11	0.67–1.82	1.07	0.64–1.77
Relative height at 15 or 16*a
Shortest/much shorter	29/40	0.63	0.36–1.10	0.61	0.35–1.07	27/23	1.11	0.58–2.12	1.16	0.60–2.23
Somewhat shorter	62/84	0.67	0.45–1.02	0.65	0.43–0.99	68/68	1.00	0.64–1.57	1.07	0.68–1.70
About the same	193/168	REF		REF		188/147	REF		REF
Somewhat taller	66/62	0.82	0.53–1.26	0.78	0.50–1.22	52/53	0.88	0.54–1.44	0.88	0.54–1.45
Tallest/much taller	50/39	1.07	0.65–1.75	1.05	0.63–1.76	36/31	1.17	0.66–2.09	1.12	0.62–2.01
Relative weight at 7 or 8*a
Thinnest/much thinner	81/72	1.08	0.71–1.64	1.06	0.69–1.62	58/48	0.85	0.51–1.42	0.70	0.41–1.18
Somewhat thinner	79/67	1.22	0.81–1.84	1.21	0.80–1.84	82/61	0.86	0.55–1.35	0.72	0.45–1.14
About the same	169/185	REF		REF		161/127	REF		REF
Somewhat heavier	58/50	1.30	0.82–2.06	1.49	0.92–2.40	58/70	0.60	0.38–0.96	0.67	0.41–1.10
Heaviest/much heavier	14/19	0.86	0.41–1.84	0.96	0.43–2.12	11/16	0.51	0.21–1.22	0.72	0.29–1.84
Relative weight at menarche*a
Thinnest/much thinner	64/65	0.73	0.47–1.14	0.68	0.43–1.08	41/37	0.66	0.37–1.16	0.56	0.31–1.02
Somewhat thinner	71/71	0.83	0.55–1.26	0.80	0.52–1.22	88/55	1.14	0.73–1.80	1.02	0.64–1.63
About the same	181/160	REF		REF		164/126	REF		REF
Somewhat heavier	69/81	0.78	0.52–1.18	0.85	0.55–1.31	69/87	0.52	0.33–0.80	0.60	0.38–0.95
Heaviest/much heavier	15/16	0.93	0.43–2.00	1.21	0.53–2.74	9/16	0.36	0.14–0.92	0.46	0.16–1.30
Relative weight at 15 or 16*a
Thinnest/much thinner	52/61	0.64	0.40–1.02	0.59	0.36–0.96	35/31	0.77	0.42–1.40	0.66	0.36–1.23
Somewhat thinner	77/73	0.93	0.62–1.39	0.90	0.59–1.35	90/53	1.35	0.87–2.11	1.23	0.78–1.95
About the same	196/174	REF		REF		179/151	REF		REF
Somewhat heavier	63/69	0.85	0.56–1.30	1.02	0.65–1.61	58/73	0.63	0.40–1.00	0.77	0.47–1.26
Heaviest/much heavier	13/16	0.78	0.36–1.71	1.14	0.46–2.85	9/14	0.47	0.18–1.22	0.65	0.22–1.89
BMI at age 20 yrs.b
<25	357/343	REF		REF		342/282	REF		REF
25–29.9	27/28	1.06	0.59–1.89	0.98	0.53–1.82	17/21	0.69	0.33–1.44	0.82	0.38–1.77
≥30	5/15	0.32	0.11–0.92	0.29	0.09–0.86	4/16	0.10	0.03–0.39	0.15	0.04–0.60
p for trend			0.11		0.07			0.001		0.01
Weight gain since age 20, kgc
Q 1 (≤7.57)	93/86	REF		REF		75/63	REF		REF
Q 2 (7.58–14.57)	85/87	0.91	0.58–1.43	0.88	0.55–1.40	77/62	0.90	0.53–1.52	0.97	0.56–1.66
Q 3 (14.58–24.52)	75/76	0.70	0.43–1.13	0.64	0.36–1.13	91/73	0.78	0.47–1.31	0.90	0.52–1.57
Q 4 (>24.52)	63/71	0.63	0.37–1.04	0.51	0.23–1.16	90/78	0.68	0.41–1.14	0.95	0.46–1.95
p for trend			0.05		0.10			0.13		0.88

^*compared to peers

OR1: Adjusted for age, ethnicity, country of origin, education, family history of breast cancer, history of benign breast disease, age at menarche, age at menopause (for postmenopausal women), parity, breastfeeding status, age at first birth, HRT use, oral contraceptive use.

OR2:

^afurther adjusted for BMI at age 20;

^bfurther adjusted for height and weight at menarche;

^cfurther adjusted for current BMI