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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Curr Hematol Malig Rep. 2013 Mar;8(1):10.1007/s11899-012-0150-1. doi: 10.1007/s11899-012-0150-1

Figure 1. BCR-ABL1-induced signaling pathways in CML.

Figure 1

Schematic representation of the myriad signaling pathways that are activated in CML cells. Phosphorylation is represented by red “P” symbols. Arrowheads indicate activation of a downstream molecule, while a bar at the end of a line indicates inhibition of a downstream molecule. (Adapted from Goldman and Melo, N. Eng. J. Med 2003;349:1451).