Table 2.
All participant and observer rated, motor/cognitive, and physiological outcome measures (peak measures for those for which timecourse was assessed) for which either 1) a significant planned comparison effect was found for at least 1 dose of either drug compared to placebo, or 2) a significant effect was found in the planned contrast comparing the least-squares adjusted mean of the highest 3 doses between each drug.
| Measure | Drug vs placebo a | Drug vs drug b | |
|---|---|---|---|
|
| |||
| GHB vs PL | ETOH vs PL | GHB vs ETOH | |
| Participant & Observer Rated | |||
| Alertness/sleepiness VAS (SEQ) | + | + | NS |
| Drug Effect (SEQ) | + | + | NS |
| Arousing (SEQ) | + | + | NS |
| Depressant (SEQ) | + | + | NS |
| Like (SEQ) | + | + | NS |
| Good Effect (SEQ) | + | + | NS |
| Bad Effect (SEQ) | + | + | NS |
| Headache (SEQ) | NS | + | ETOH > GHB |
| Confused (SEQ) | + | + | NS |
| Sleepy (SEQ) | + | + | NS |
| Blurred Vision (SEQ) | + | + | GHB > ETOH |
| Limp (SEQ) | + | + | NS |
| Lightheaded (SEQ) | + | + | GHB > ETOH |
| Queasy (SEQ) | + | + | NS |
| Fatigued (SEQ) | + | + | NS |
| Unsteady (SEQ) | + | + | NS |
| Hot (SEQ) | + | + | NS |
| Diff. Concentrating (SEQ) | + | + | NS |
| Slurred Speech (SEQ) | + | + | NS |
| Mentally slow (SEQ) | + | + | NS |
| Heavy limbs (SEQ) | + | + | NS |
| Tired (SEQ) | + | + | NS |
| Easy going (SEQ) | + | + | NS |
| Forgetful (SEQ) | + | + | NS |
| Talkative (SEQ) | + | + | NS |
| Excited (SEQ) | NS | + | NS |
| Comfortable (SEQ) | + | NS | GHB > ETOH |
| Relaxed (SEQ) | + | NS | NS |
| Nervous (SEQ) | + | + | NS |
| Numbness (SEQ) | + | + | NS |
| Restless (SEQ) | NS | + | NS |
| Dry Mouth (SEQ) | + | + | NS |
| Shaky (SEQ) | + | + | NS |
| Irritable (SEQ) | NS | + | NS |
| Drug Effect (DEQ) | + | + | NS |
| Liking (DEQ) | + | + | NS |
| PEQ (DEQ) | + | + | NS |
| Disliking (DEQ) | NS | + | NS |
| PCAG (ARCI) | + | + | GHB > ETOH |
| Benzedrine (ARCI) | − | − | GHB > ETOH |
| Amphetamine (ARCI) | NS | + | NS |
| MBG (ARCI) | NS | + | NS |
| LSD (ARCI) | + | + | GHB > ETOH |
| Euphoria (ARCI) | + | + | NS |
| Sedation (ARCI) | + | + | GHB > ETOH |
| Drug effect (NDQ) | + | + | NS |
| Liking (NDQ) | + | + | GHB > ETOH |
| Disliking (NDQ) | NS | + | NS |
| Good effects (NDQ) | + | + | GHB > ETOH |
| Bad effects (NDQ) | + | + | NS |
| Take again (NDQ) | + | + | GHB > ETOH |
| DE worth (NDQ) | + | + | NS |
| Willing to pay (NDQ) | + | + | NS |
| Hangover rating | NS | + | ETOH > GHB |
| Crossover point (MCP) | NS | − | GHB > ETOH |
| DSST Performance Estimate | NS | − | NS |
| Cir Lights Performance Estimate | NS | − | NS |
| Word Recall Performance Estimate | − | − | NS |
| Level of Alertness (Observer) | − | − | GHB > ETOH |
| Relaxed (Observer) | + | + | NS |
| Speech (Observer) | + | + | NS |
| Confused (Observer) | + | + | NS |
| Stimulated (Observer) | + | + | NS |
| Drug effect (Observer) | + | + | NS |
| Posture (Observer) | + | + | NS |
| Sleep Time (Observer) | + | + | NS |
| Total Sleep Time (Observer) | + | + | NS |
| Motor/Cognitive | |||
| Immediate trials (Digit recall) | − | − | NS |
| Word Recall | NS | − | NS |
| Word Recognition d′ | − | − | ETOH > GHB |
| DSST | − | − | NS |
| Balance | − | − | NS |
| Circular lights | − | − | NS |
| Physiological | |||
| Systolic | + | + | NS |
| Diastolic | − | − | NS |
| Pulse | + | + | ETOH > GHB |
These two columns show the results of planned comparisons of placebo with 12, 24, 48, and 120 g/70 kg ETOH and 1, 2, 4, 6, 8, and 10 g/70 kg GHB. Symbol (+ or −) indicates that at least one dose of the drug was significantly different from placebo (p ≤ .05); symbol (+ or −) also indicates the direction of the drug effect relative to placebo. For the alertness/sleepiness VAS, higher scores denote sleepiness. For performance estimates, + indicates that participants underestimated performance relative to actual performance more so for the drug than placebo. NS indicates no dose of that drug was different from placebo.
This column shows the results of a planned contrast comparing the mean of the top 3 doses of GHB (6, 8, 10 g/70kg) to the mean of the top 3 doses of ETOH (72, 96, 120 g/70kg). The drug to the left of the symbol (>) produced a significantly greater effect. NS indicates that the effects produced by the doses of the two drugs were not significantly different.