Table 5.
Comparison of Expression of Transcription Factors, Ion Channels, Na+–K+ Pump, Exchangers, Ca2+‐Handling Proteins, and Connexins Between Regions of Interest
| Transcript | Retroaortic Node vs Ventricular Muscle | Right AV Ring vs Ventricular Muscle | Retroaortic Node vs Atrial Muscle | Right AV Ring vs Atrial Muscle | Retroaortic Node vs SN | Right AV Ring vs SN | Retroaortic Node vs AV Node | Right AV Ring vs AV Node | Retroaortic Node vs Right AV Ring |
|---|---|---|---|---|---|---|---|---|---|
| Transcription factors | |||||||||
| Id2 | ↑ | ↑ | = | = | = | = | = | = | = |
| Msx1 | = | = | = | = | = | = | = | = | = |
| Msx2 | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | = | = | = |
| Tbx3 | ↑ | ↑ | ↑ | ↑ | = | = | = | = | = |
| Tbx5 | ↑ | ↑ | = | = | = | = | = | ↑ | = |
| Nkx2.5 | = | ↑ | = | = | = | = | = | = | = |
| GATA4 | = | ↑ | = | = | = | = | = | = | = |
| GATA6 | ↑ | = | = | = | = | = | = | = | = |
| Inward current carrying ion channels | |||||||||
| Nav1.1 | ↑ | = | = | = | = | = | = | = | = |
| Nav1.5 | = | = | ↓ | = | ↓ | = | = | = | = |
| Navβ1 | ↑ | ↑ | = | = | = | = | = | = | = |
| Navβ4 | ↓ | = | = | = | = | = | = | = | = |
| Cav1.2 | = | = | = | = | = | = | = | = | = |
| Cav1.3 | = | = | = | = | = | = | = | ↓ | = |
| Cav3.1 | ↑ | ↑ | = | = | = | = | = | = | = |
| Cav3.2 | ↑ | ↑ | = | = | = | = | = | = | = |
| HCN1 | ↑ | ↑ | ↑ | ↑ | ↓ | = | = | = | = |
| HCN2 | ↓ | ↓ | = | = | = | = | = | = | = |
| HCN4 | ↑ | ↑ | ↑ | ↑ | ↓ | = | = | = | = |
| Outward current carrying K+ channels | |||||||||
| Kv1.2 | = | = | ↓ | = | = | = | = | = | = |
| Kv1.4 | = | = | = | = | = | = | = | = | = |
| Kv1.5 | ↑ | ↑ | ↑ | ↑ | = | = | = | = | = |
| Kv2.1 | = | = | = | = | = | = | = | = | = |
| Kv4.2 | = | = | = | = | = | = | ↑ | = | = |
| Kv4.3 | = | = | = | = | = | = | = | ↑ | = |
| KvLQT1 (Kv7.1) | = | = | = | = | = | = | = | = | = |
| ERG (Kv11.1) | = | ↑ | = | = | = | = | = | = | = |
| KChIP2 | = | = | = | = | = | = | = | ↑ | = |
| Kvβ1 | = | ↑ | = | ↑ | = | = | ↑ | ↑ | = |
| SK1 (KCa2.1) | ↑ | ↑ | = | ↑ | = | = | = | = | = |
| SK2 (KCa2.2) | = | = | = | = | = | = | = | = | = |
| SK3 (KCa2.3) | = | ↑ | = | ↑ | = | = | = | = | = |
| Kir2.1 | ↓ | ↓ | = | = | = | = | = | = | = |
| Kir2.2 | ↑ | ↑ | = | = | = | = | = | = | = |
| Kir3.1 | ↑ | ↑ | ↓ | ↓ | = | = | = | = | = |
| Kir3.4 | ↑ | ↑ | = | = | = | = | = | = | = |
| Kir6.1 | = | = | = | = | = | = | = | = | = |
| Kir6.2 | = | = | = | = | = | = | = | = | = |
| SUR1 | = | ↑ | = | = | = | = | = | ↑ | = |
| SUR2 | ↓ | = | ↓ | = | = | = | = | = | = |
| TREK1 (K2P2.1) | = | = | = | = | = | = | = | = | = |
| TASK1 (K2P3.1) | = | = | = | ↓ | = | = | = | = | = |
| TASK2 (K2P5.1) | ↑ | ↑ | = | = | = | = | = | = | = |
| TWIK2 (K2P6.1) | ↑ | ↑ | = | = | = | = | = | = | = |
| Na+–K+ pump and exchangers | |||||||||
| Na+–K+ pump α3 | ↑ | ↑ | ↑ | ↑ | = | = | = | = | = |
| Na+–H+ exchanger | ↑ | ↑ | = | = | = | = | = | = | = |
| NCX1 | ↑ | ↑ | = | = | = | = | = | = | = |
| Ca2+‐handling proteins | |||||||||
| SERCA2a | = | ↑ | = | = | = | = | = | = | = |
| Phospholamban | = | = | = | = | = | = | = | = | = |
| Sarcolipin | ↑ | ↑ | = | = | = | = | = | ↑ | = |
| RYR2 | = | = | = | = | = | = | = | = | = |
| RYR3 | = | ↑ | = | = | = | = | = | = | = |
| Gap junction channels | |||||||||
| Gja5/Cx40 | = | ↑ | = | = | = | = | = | = | = |
| Gja1/Cx43 | = | = | ↓ | = | = | = | = | = | = |
| Gja7/Cx45 | ↑ | ↑ | = | = | = | = | = | = | = |
AV indicates atrioventricular; SN, sinus node; ↑, significantly upregulated; ↓, significantly downregulated; =, no difference.