Table 6.
Cox Proportional Hazards Analysis for Cardiovascular Events
| Variable | Univariate | Multivariate Model 1 | Multivariate Model 2 | Multivariate Model 3 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value | |
| Male sex | 1.211 | 0.789 to 1.859 | 0.381 | Not selected | 1.178 | 0.730 to 1.901 | 0.502 | — | — | — | ||
| Age, per year | 1.043 | 1.022 to 1.065 | <0.0001 | 1.024 | 1.000 to 1.048 | 0.046 | 1.029 | 1.002 to 1.056 | 0.038 | — | — | — |
| Body mass index, per kg/m2 | 0.925 | 0.872 to 0.982 | 0.011 | 0.950 | 0.894 to 1.010 | 0.103 | 0.947 | 0.885 to 1.013 | 0.113 | — | — | — |
| Current smoking | 1.162 | 0.737 to 1.833 | 0.519 | Not selected | 1.284 | 0.780 to 2.113 | 0.325 | — | — | — | ||
| Hypertension | 1.426 | 0.826 to 2.465 | 0.203 | Not selected | 1.306 | 0.731 to 2.335 | 0.367 | — | — | — | ||
| Diabetes mellitus | 1.135 | 0.774 to 1.665 | 0.517 | Not selected | 1.214 | 0.811 to 1.819 | 0.346 | — | — | — | ||
| HDL cholesterol, per mg/dL | 0.994 | 0.980 to 1.007 | 0.376 | Not selected | 1.009 | 0.994 to 1.024 | 0.233 | — | — | — | ||
| LDL cholesterol, per mg/dL | 0.994 | 0.988 to 1.001 | 0.081 | Not selected | 0.999 | 0.992 to 1.006 | 0.775 | — | — | — | ||
| Ln BNP, per 0.1 | 1.036 | 1.019 to 1.052 | <0.0001 | 1.019 | 1.002 to 1.037 | 0.023 | 1.018 | 1.000 to 1.037 | 0.050 | 1.026 | 1.009 to 1.044 | 0.003 |
| Ln hsCRP, per 0.1 | 1.008 | 0.998 to 1.019 | 0.125 | Not selected | 1.004 | 0.993 to 1.015 | 0.514 | 1.001 | 0.991 to 1.012 | 0.813 | ||
| LVEF, per % | 0.977 | 0.952 to 1.003 | 0.081 | Not selected | 0.997 | 0.970 to 1.026 | 0.859 | 1.004 | 0.977 to 1.032 | 0.778 | ||
| eGFR, per mL/min per 1.73 m2 | 0.985 | 0.975 to 0.996 | 0.0067 | Not selected | 1.000 | 0.989 to 1.012 | 0.951 | 0.997 | 0.986 to 1.008 | 0.550 | ||
| Coronary artery disease | 8.587 | 2.720 to 27.11 | 0.0003 | Not selected | 1.110 | 0.310 to 3.980 | 0.873 | 1.577 | 0.433 to 5.747 | 0.490 | ||
| SYNTAXsc, per tertile increment | 2.854 | 2.167 to 3.759 | <0.0001 | 2.426 | 1.825 to 3.225 | <0.0001 | 2.447 | 1.781 to 3.361 | <0.0001 | 2.360 | 1.736 to 3.208 | <0.0001 |
| FRS, per tertile increment | 1.445 | 1.126 to 1.854 | 0.0038 | — | — | — | — | — | — | 0.976 | 0.740 to 1.288 | 0.863 |
| RHI, per 0.1 | 0.693 | 0.614 to 0.781 | <0.0001 | 0.761 | 0.673 to 0.859 | <0.0001 | 0.757 | 0.666 to 0.860 | <0.0001 | 0.771 | 0.681 to 0.873 | <0.0001 |
Multivariate analysis Model 1 was performed using a backward algorithm with a 0.20 significance level. Model 2 and 3 was performed using a forced entry algorithm. Model 2; gender, age, body mass index, smoking, hypertension, diabetes mellitus, HDL cholesterol, LDL cholesterol, BNP, hsCRP, LVEF, eGFR, coronary artery disease, SYNTAXsc, and RHI. Model 3; FRS, BNP, hsCRP, LVEF, eGFR, coronary artery disease, SYNTAXsc, and RHI. BNP indicates B‐type natriuretic peptide; CI, confidence interval; eGFR, estimated glomerular filtration rate; FRS, Framingham Risk Score; HDL, high‐density lipoprotein; HR, hazard ratio; hsCRP, high‐sensitivity C‐reactive protein; LDL, low‐density lipoprotein; LVEF, left ventricular ejection fraction; RHI, reactive hyperemia‐peripheral arterial tonometry index; SYNTAXsc, Synergy Between PCI With Taxus and Cardiac Surgery score.