Table 8.
C‐Statistics for Cox Proportional Hazards Models to Predict Cardiovascular Events
| C‐Statistics (95% CI) | Increment in C‐Statistics (95% CI) | P Value | |
|---|---|---|---|
| All High‐Risk Patients (n=528) | |||
| FRS | 0.596 (0.540 to 0.653) | 0.0002 | |
| FRS+RHI | 0.699 (0.655 to 0.743) | 0.103 (0.048 to 0.158) | |
| FRS+BNP | 0.640 (0.588 to 0.692) | 0.0055 | |
| FRS+BNP+RHI | 0.706 (0.664 to 0.747) | 0.066 (0.019 to 0.112) | |
| FRS+SYNTAXsc | 0.733 (0.683 to 0.782) | 0.017 | |
| FRS+SYNTAXsc+RHI | 0.774 (0.736 to 0.812) | 0.041 (0.008 to 0.075) | |
| FRS+BNP+SYNTAXsc | 0.728 (0.679 to 0.778) | 0.031 | |
| FRS+BNP+SYNTAXsc+RHI | 0.766 (0.726 to 0.806) | 0.038 (0.004 to 0.072) | |
| CAD Patients (n=442) | |||
| FRS | 0.510 (0.448 to 0.572) | <0.0001 | |
| FRS+RHI | 0.654 (0.603 to 0.704) | 0.144 (0.078 to 0.209) | |
| FRS+BNP | 0.610 (0.553 to 0.667) | 0.0094 | |
| FRS+BNP+RHI | 0.676 (0.631 to 0.720) | 0.066 (0.016 to 0.115) | |
| FRS+SYNTAXsc | 0.682 (0.624 to 0.740) | 0.0070 | |
| FRS+SYNTAXsc+RHI | 0.733 (0.689 to 0.776) | 0.051 (0.014 to 0.088) | |
| FRS+BNP+SYNTAXsc | 0.694 (0.638 to 0.751) | 0.046 | |
| FRS+BNP+SYNTAXsc+RHI | 0.735 (0.692 to 0.779) | 0.042 (0.001 to 0.083) | |
BNP, SYNTAXsc, and RHI were incorporated as continuous variables. We used natural logarithmic transformations of BNP and SYNTAXsc because of skewed distributions. BNP indicates B‐type natriuretic peptide; CAD, coronary artery disease; CI, confidence interval; FRS, Framingham Risk Score; RHI, reactive hyperemia‐peripheral arterial tonometry index; SYNTAXsc, Synergy Between PCI With Taxus and Cardiac Surgery score.