Table 9.

Reclassification by RHI Addition to the FRS Alone and the FRS, BNP and SYNTAXsc in CAD Patients (n=442)

	Low‐Intermediate Risk	High Risk	Very High Risk
Risk Category by FRS Alone	New Risk Category Using FRS+RHI
Patients Without Cardiovascular Events
Low‐intermediate risk	0	0	0
High risk	65	117	88
Very high risk	4	33	33
Patients With Cardiovascular Events
Low‐intermediate risk	0	0	0
High risk	3	28	41
Very high risk	2	5	23

Risk Category Using FRS+BNP+SYNTAXsc	New Risk Category Using FRS+BNP+SYNTAXsc+RHI
Patients Without Cardiovascular Events
Low‐intermediate risk	54	19	0
High risk	59	80	22
Very high risk	15	23	68
Patients With Cardiovascular Events
Low‐intermediate risk	2	4	0
High risk	4	16	18
Very high risk	1	4	53

According to the Framingham Risk Score, which was calculated for a 2‐year cardiovascular event risk, low‐intermediate risk was <12%, high risk was 12% to 25%, and very high risk was more than 25%. The overall net reclassification index was 34.5%, P<0.0001 when used in combination with FRS alone, and 29.2%, P<0.0001 when used in combination with FRS+BNP+SYNTAXsc. BNP indicates B‐type natriuretic peptide; CAD, coronary artery disease; FRS, Framingham Risk Score; RHI, reactive hyperemia‐peripheral arterial tonometry index; SYNTAXsc, Synergy Between PCI With Taxus and Cardiac Surgery score.