Table 11.
C‐Statistics for Cox Proportional Hazards Models to Predict Cardiovascular Events
| C‐Statistics (95% CI) | Increment in C‐Statistics (95% CI) | P Value | |
|---|---|---|---|
| All High‐Risk Patients (n=526) | |||
| FRS | 0.596 (0.539 to 0.659) | 0.022 | |
| FRS+Ln_RH‐PAT ratio | 0.659 (0.608 to 0.709) | 0.062 (0.009 to 0.116) | |
| FRS+BNP | 0.652 (0.570 to 0.733) | 0.080 | |
| FRS+BNP+Ln_RH‐PAT ratio | 0.688 (0.623 to 0.753) | 0.036 (−0.004 to 0.076) | |
| FRS+SYNTAXsc | 0.733 (0.690 to 0.776) | 0.119 | |
| FRS+SYNTAXsc+Ln_RH‐PAT ratio | 0.753 (0.709 to 0.797) | 0.020 (−0.005 to 0.045) | |
| FRS+BNP+SYNTAXsc | 0.740 (0.679 to 0.801) | 0.072 | |
| FRS+BNP+SYNTAXsc+Ln_RH‐PAT ratio | 0.760 (0.704 to 0.816) | 0.020 (−0.002 to 0.041) | |
| CAD Patients (n=440) | |||
| FRS | 0.510 (0.440 to 0.580) | 0.0030 | |
| FRS+Ln_RH‐PAT ratio | 0.603 (0.545 to 0.661) | 0.093 (0.032 to 0.154) | |
| FRS+BNP | 0.610 (0.511 to 0.709) | 0.0998 | |
| FRS+BNP+Ln_RH‐PAT ratio | 0.645 (0.570 to 0.719) | 0.035 (−0.007 to 0.076) | |
| FRS+SYNTAXsc | 0.682 (0.630 to 0.733) | 0.0596 | |
| FRS+SYNTAXsc+Ln_RH‐PAT ratio | 0.709 (0.657 to 0.761) | 0.028 (−0.001 to 0.056) | |
| FRS+BNP+SYNTAXsc | 0.694 (0.622 to 0.766) | 0.0693 | |
| FRS+BNP+SYNTAXsc+Ln_RH‐PAT ratio | 0.717 (0.650 to 0.784) | 0.023 (−0.002 to 0.047) | |
BNP, SYNTAXsc, and RHI were incorporated as continuous variables. We used natural logarithmic transformations of BNP and SYNTAXsc because of skewed distributions. BNP indicates B‐type natriuretic peptide; CAD, coronary artery disease; CI, confidence interval; FRS, Framingham Risk Score; RHI, reactive hyperemia‐peripheral arterial tonometry index; RH‐PAT, reactive hyperemia‐peripheral arterial tonometry; SYNTAXsc, Synergy Between PCI With Taxus and Cardiac Surgery score.