Table 12.

Reclassification by Ln_RH‐PAT Ratio Addition to FRS Alone and FRS, BNP, and SYNTAXsc (n=526)

	Low‐Intermediate Risk	High Risk	Very High Risk
Risk Category Using FRS Alone	New Risk Category Using FRS+Ln_RH‐PAT Ratio
Patients Without Cardiovascular Events
Low‐intermediate risk	2	0	0
High risk	128	175	93
Very high risk	6	13	15
Patients With Cardiovascular Events
Low‐intermediate risk	0	0	0
High risk	8	40	43
Very high risk	0	5	8

Risk Category Using FRS+BNP+SYNTAXsc	New Risk Category by FRS+BNP+SYNTAXsc+Ln_RH‐PAT Ratio
Patients Without Cardiovascular Events
Low‐intermediate risk	134	30	0
High risk	45	92	25
Very high risk	7	26	63
Patients With Cardiovascular Events
Low‐intermediate risk	6	4	0
High risk	2	19	18
Very high risk	1	3	51

According to the Framingham Risk Score that was calculated for a 2‐year cardiovascular event risk, low‐intermediate risk was <12%, high risk was 12% to 25%, and very high risk was >25%. The overall net reclassification index was 41.3%, P<0.0001 when Ln_RH‐PAT ratio was used in conjunction with FRS alone, and 20.8%, P=0.0003 when used in conjunction with FRS+BNP+SYNTAXsc. BNP indicates B‐type natriuretic peptide; FRS, Framingham Risk Score; RH‐PAT, reactive hyperemia‐peripheral arterial tonometry; SYNTAXsc, Synergy Between PCI With Taxus and Cardiac Surgery score.