Table 13.

Reclassification by Ln_RH‐PAT Ratio Addition to the FRS Alone and the FRS, BNP, and SYNTAXsc in CAD Patients (n=440)

	Low‐Intermediate Risk	High Risk	Very High Risk
Risk Category by FRS Alone	New Risk Category Using FRS+Ln_RH‐PAT Ratio
Patients Without Cardiovascular Events
Low‐intermediate risk	0	0	0
High risk	46	132	91
Very high risk	2	28	40
Patients With Cardiovascular Events
Low‐intermediate risk	0	0	0
High risk	2	29	41
Very high risk	1	10	18

Risk Category Using FRS+BNP+SYNTAXsc	New Risk Category Using FRS+BNP+Syntaxsc+Ln_RH‐PAT Ratio
Patients Without Cardiovascular Events
Low‐intermediate risk	54	19	0
High risk	41	95	24
Very high risk	5	36	65
Patients With Cardiovascular Events
Low‐intermediate risk	3	3	0
High risk	1	21	16
Very high risk	1	4	52

According to the Framingham Risk Score, which was calculated for a 2‐year cardiovascular event risk, low‐intermediate risk was <12%, high risk was 12% to 25%, and very high risk was more than 25%. The overall net reclassification index was 23.3%, P=0.0045 when used in combination with FRS alone, and 24.4%, P<0.0001 when used in combination with FRS+BNP+SYNTAXsc. BNP indicates B‐type natriuretic peptide; CAD, coronary artery disease; FRS, Framingham Risk Score; RH‐PAT, reactive hyperemia‐peripheral arterial tonometry; SYNTAXsc, Synergy Between PCI With Taxus and Cardiac Surgery score.