Table 4.
Metabolism Genes Differentially Regulated in fatVHLko Adipose Tissue (n=3)
| Gene | NCBI Accession | FDR Adjusted P Value | Fold‐Change (KO vs WT) |
|---|---|---|---|
| Aldh3b2 (aldehyde dehydrogenase) | NM_001177438 | 0.011 | 3.73 |
| Slc2a3 (solute carrier family 2, member 3 or Glut3) | NM_011401 | 0.007 | 3.26 |
| Slc25a10 (mitochondrial carrier, dicarb) | NM_013770 | 0.021 | 3.23 |
| Slc27a1 (fatty acid transporter) | NM_011977 | 0.004 | 3.22 |
| Lep (leptin) | NM_008493 | 0.047 | 3.08 |
| Fads3 (fatty acid desaturase 3) | NM_021890 | 0.029 | 2.80 |
| Aldh1 l1 (aldehyde dehydrogenase 1 family, member L1) | NM_027406 | 0.007 | 2.52 |
| Abcd2 (ATP‐binding cassette, subfamily D, member 2 or Aldl1 or Aldrp) | NM_011994 | 0.034 | 2.28 |
| Fmo2 (flavin containing monooxygenase) | NM_018881 | 0.025 | 2.22 |
| Cbr3 (carbonyl reductase) | NM_173047 | 0.018 | 2.20 |
| Gpx8 (glutathione peroxidase) | NM_027127 | 0.004 | 2.09 |
| Fads1 (fatty acid desaturase 1) | NM_146094 | 0.025 | 2.08 |
| Pxmp2 (peroxisomal membrane protein) | NM_008993 | 0.006 | 2.01 |
| Ndufa4l2 (NADH dehydrogenase [ubiquinone] 1a subcomplex) | NM_001098789 | 0.007 | 2.01 |
| Gpd2 (glycerol phosphate dehydrogenase) | NM_010274 | 0.006 | −2.01 |
| Pgam2 (phosphoglycerate mutase) | NM_018870 | 0.038 | −2.01 |
| Pfkl (phosphofructokinase) | NM_008826 | 0.004 | −2.07 |
| Fabp3 (fatty acid binding protein 3) | NM_010174 | 0.020 | −2.08 |
| Acsm1 (acyl‐CoA synthetase medium‐chain family) | NM_054094 | 0.035 | −2.16 |
| Ppargc1a (peroxisome proliferative activated receptor g coactivator 1a) | NM_008904 | 0.018 | −2.21 |
| Ptger3 (prostaglandin E receptor) | NM_011196 | 0.015 | −2.23 |
| Acsl5 (acyl‐CoA synthetase long‐chain family) | NM_027976 | 0.004 | −2.46 |
| Apoa5 (apolipoprotein A‐V) | NM_080434 | 0.017 | −2.54 |
| Ahcy (S‐adenosylhomocysteine hydrolase) | NM_016661 | 0.016 | −2.64 |
| Slc3a1 (solute carrier family 3, member 1) | NM_009205 | 0.036 | −2.64 |
| Slc27a5 (solute carrier family 27 [fatty acid transporter], member 5) | NM_009512 | 0.031 | −2.81 |
| Akr1c14 (aldo‐keto reductase family) | NM_134072 | 0.031 | −2.84 |
| Apom (apolipoprotein M) | NM_018816 | 0.038 | −3.01 |
| Me3 (malic enzyme) | NM_181407 | 0.006 | −3.38 |
| Upp2 (uridine phosphorylase) | NM_029692 | 0.038 | −3.42 |
| Gyk (glycerol kinase) | NM_212444 | 0.022 | −3.43 |
| Aldh8a1 (aldehyde dehydrogenase 8 family, member A1) | NM_178713 | 0.038 | −3.56 |
| Apoc4 (apolipoprotein C‐IV) | NM_007385 | 0.033 | −3.57 |
| Ugt3a1 (UDP glycosyltransferase 3a1) | NM_207216 | 0.047 | −3.95 |
| G6pc (glucose‐6‐phosphatase) | NM_008061 | 0.032 | −4.03 |
| Angptl3 (angiopoietin‐like 3) | NM_013913 | 0.042 | −4.06 |
| Aass (aminoadipate‐semialdehyde synthase) | NM_013930 | 0.030 | −4.64 |
| Elovl2 (elongation of very long chain fatty acids) | NM_019423 | 0.027 | −4.64 |
| Ugt3a2 (UDP glycosyltransferase 3a2) | NM_144845 | 0.040 | −5.50 |
| Ugt2a3 (UDP glycosyltransferase 3a2) | NM_028094 | 0.026 | −6.20 |
| Akr1c6 (aldo‐keto reductase family) | NM_030611 | 0.040 | −8.05 |
| Ucp1 (uncoupling protein) | NM_009463 | 0.004 | −13.10 |
FDR indicates false discovery rate; KO, knockout; NCBI, National Center for Biotechnology Information; WT, wild type.