Figure 8.

Echocardiographic parameters in WT and MIF^−/− mice treated with rapamycin for 7 days prior to doxorubicin (DOX) challenge. A, LV wall thickness; B, septal thickness; C, fractional shortening (FS, %); D, LVEDD; E, LVESD; F, ejection fraction (EF, %). Mean±SEM, n=8 to 9 mice per group, *P<0.05 vs WT group, ^#P<0.05 vs WT DOX group, ^†P<0.05 vs MIF knockout DOX group. ko indicates knockout; LV, left ventricle; LVEDD, LV end diastolic diameter; LVESD, LV end systolic diameter; MIF, macrophage migration inhibitory factor; Rapa, rapamycin; WT, wild type.