Table 3.
IR (Per 1000 Person Years) and HR of PD or MCI Related to Other Invasive Vascular Procedures or Diseases at Baseline
| Number subjects | PD | MCI | PD or MCI | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number Events | Follow‐up Years, Mean (SD) | IR | Min. Adjusted*, HR (95% CI) | Fully Adjusted*, HR (95% CI) | Number of Events | Follow‐up Years, Mean (SD) | IR | Min. Adjusted*, HR (95% CI) | Fully Adjusted*, HR (95% CI) | Number of Events | Follow‐up Years, Mean (SD) | IR | Min. Adjusted*, HR (95% CI) | Fully Adjusted*, HR (95% CI) | ||
| Other* | ||||||||||||||||
| Absent | 6148 | 173 | 7.7 (2.5) | 3.7 | 1 | 1 | 264 | 7.6 (2.6) | 5.6 | 1 | 1 | 374 | 7.6 (2.6) | 8.0 | 1 | 1 |
| Present | 282 | 13 | 7.1 (2.7) | 6.5 | 1.62 (0.92, 2.85) | 1.60 (0.88, 2.90) | 27 | 6.8 (2.8) | 14.1 | 2.41 (1.62, 3.60) | 2.35 (1.53, 3.61) | 33 | 6.8 (2.8) | 17.3 | 2.02 (1.41, 2.89) | 1.97 (1.34, 2.87) |
| Coronary bypass surgery | ||||||||||||||||
| Absent | 6356 | 182 | 7.7 (2.5) | 3.7 | 1 | 1 | 280 | 7.6 (2.6) | 5.8 | 1 | 1 | 394 | 7.6 (2.6) | 8.2 | 1 | 1 |
| Present | 77 | 4 | 6.8 (2.9) | 7.7 | 1.81 (0.67, 4.90) | 1.49 (0.53, 4.19) | 11 | 6.4 (3.0) | 22.3 | 3.81 (2.08, 6.99) | 3.20 (1.66, 6.15) | 13 | 6.3 (3.0) | 26.6 | 3.22 (1.85, 5.61) | 2.63 (1.46, 4.75) |
| Angioplasty | ||||||||||||||||
| Absent | 6330 | 181 | 7.7 (2.5) | 3.7 | 1 | 1 | 283 | 7.6 (2.6) | 5.9 | 1 | 1 | 396 | 7.6 (2.6) | 8.3 | 1 | 1 |
| Present | 103 | 5 | 7.2 (2.5) | 6.7 | 1.90 (0.78, 4.64) | 1.76 (0.70, 4.42) | 8 | 7.1 (2.6) | 10.9 | 1.97 (0.97, 3.98) | 1.73 (0.83, 3.62) | 11 | 7.1 (2.6) | 15.1 | 1.89 (1.04, 3.45) | 1.67 (0.89, 3.13) |
| Carotid endarteretomy | ||||||||||||||||
| Absent | 6409 | 183 | 7.7 (2.5) | 3.7 | 1 | 1. | 287 | 7.6 (2.6) | 5.9 | 1 | 1 | 402 | 7.6 (2.6) | 8.3 | 1 | 1 |
| Present | 24 | 3 | 6.9 (2.7) | 18.2 | 3.92 (1.24, 12.4) | 4.28 (1.32, 13.9) | 4 | 6.3 (3.0) | 26.6 | 3.30 (1.22, 8.93) | 3.17 (1.15, 8.74) | 5 | 6.2 (3.0) | 33.4 | 3.11 (1.28, 7.58) | 3.03 (1.23, 7.47) |
| Peripheral vascular disease | ||||||||||||||||
| Absent | 6317 | 182 | 7.7 (2.5) | 3.7 | 1 | 1 | 278 | 7.6 (2.6) | 5.8 | 1 | 1 | 393 | 7.6 (2.6) | 8.2 | 1 | 1 |
| Present | 130 | 5 | 7.0 (2.7) | 5.5 | 1.20 (0.49, 2.92) | 1.22 (0.50, 3.02) | 15 | 6.7 (2.8) | 17.2 | 2.59 (1.54, 4. 37) | 2.44 (1.43, 4. 16) | 16 | 6.7 (2.8) | 18.3 | 1.86 (1.12, 3. 07) | 1.82 (1.09, 3.02) |
CI indicates confidence interval; HR, hazard ratio; HTR, Hormone Trial Randomization; IR, incidence rate; MCI, mild cognitive impairment; 3MSE, Modified Mini‐Mental State Examination; PD, probable dementia; SD, standard deviation.
Adjusted for age, education, race, HTR arm, and baseline 3MSE.
Adjusted for age, education, race, HTR arm, baseline 3MSE, alcohol intake, smoking status, physical activity, diabetes status, sleep hours, hypertension status, BMI, depression, waist‐hip ratio, hypercholesterolemia, and aspirin use.
“Other” includes coronary bypass surgery, angioplasty, carotid endarterectomy, and peripheral vascular disease.