Table 5.
Sensitivity Analysis: IR (Per 1000 Person Years) and HR of PD or MCI Related to Cardiovascular Disease Excluding Women With Incident Stroke or TIA Events
| Number subjects | PD | MCI | PD or MCI | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number Events | Follow‐up Years, Mean (SD) | IR | Min. Adjusted*, HR (95% CI) | Fully Adjusted*, HR (95% CI) | Number of Events | Follow‐up Years, Mean (SD) | IR | Min. Adjusted*, HR (95% CI) | Fully Adjusted*, HR (95% CI) | Number of Events | Follow‐up Years, Mean (SD) | IR | Min. Adjusted*, HR (95% CI) | Fully Adjusted*, HR (95% CI) | ||
| CVD* | ||||||||||||||||
| Absent | 5320 | 142 | 7.8 (2.5) | 3.4 | 1 | 1 | 217 | 7.7 (2.5) | 5.3 | 1 | 1 | 314 | 7.6 (2.6) | 7.7 | 1 | 1 |
| Present | 804 | 29 | 7.1 (2.7) | 5.1 | 1.27 (0.85, 1.91) | 1.14 (0.75, 1.74) | 61 | 6.9 (2.8) | 10.9 | 1.83 (1.37, 2.43) | 1.67 (1.24, 2.26) | 69 | 6.9 (2.8) | 12.4 | 1.41 (1.08, 1.83) | 1.26 (0.96, 1.66) |
| Myocardial infarction | ||||||||||||||||
| Absent | 5933 | 161 | 7.7 (2.5) | 3.5 | 1 | 1 | 258 | 7.6 (2.6) | 5.7 | 1 | 1 | 359 | 7.6 (2.6) | 8.0 | 1 | 1 |
| Present | 191 | 10 | 6.7 (2.9) | 7.9 | 2.00 (1.05, 3.81) | 1.96 (1.01, 3.80) | 20 | 6.5 (2.9) | 16.2 | 2.44 (1.54, 3.86) | 2.30 (1.43, 3.71) | 24 | 6.4 (2.9) | 19.5 | 2.10 (1.38, 3.18) | 1.98 (1.29, 3.04) |
| Angina pectoris | ||||||||||||||||
| Absent | 5699 | 152 | 7.7 (2.5) | 3.5 | 1 | 1 | 236 | 7.6 (2.6) | 5.4 | 1 | 1 | 336 | 7.6 (2.6) | 7.8 | 1 | 1 |
| Present | 413 | 16 | 7.1 (2.7) | 5.4 | 1.33 (0.79, 2.22) | 1.18 (0.69, 2.03) | 39 | 6.9 (2.9) | 13.7 | 2.30 (1.64, 3.23) | 1.50 (1.07, 2.10) | 42 | 6.9 (2.9) | 14.7 | 1.71 (1.24, 2.35) | 1.50 (1.07, 2.10) |
| Atrial fibrillation | ||||||||||||||||
| Absent | 5873 | 161 | 7.7 (2.5) | 3.6 | 1 | 1 | 259 | 7.6 (2.6) | 5.8 | 1 | 1 | 360 | 7.6 (2.6) | 8.1 | 1 | 1 |
| Present | 230 | 8 | 7.0 (2.7) | 4.9 | 1.14 (0.56, 2.33) | 1.01 (0.49, 2.09) | 16 | 6.9 (2.8) | 10.1 | 1.61 (0.97, 2.68) | 1.48 (0.89, 2.48) | 19 | 6.9 (2.8) | 12.0 | 1.37 (0.86, 2.18) | 1.25 (0.78, 2.00) |
| Congestive heart failure | ||||||||||||||||
| Absent | 6057 | 168 | 7.7 (2.5) | 3.6 | 1 | 1 | 271 | 7.6 (2.6) | 5.9 | 1 | 1 | 375 | 7.6 (2.6) | 8.2 | 1 | 1 |
| Present | 67 | 3 | 6.4 (2.9) | 7.0 | 1.56 (0.49, 4.97) | 1.42 (0.44, 4.53) | 7 | 6.1 (3.0) | 17.1 | 2.22 (1.03, 4.77) | 1.94 (0.90, 4.21) | 8 | 6.1 (3.0) | 19.7 | 1.80 (0.88, 3.67) | 1.54 (0.75, 3.16) |
| Other* | ||||||||||||||||
| Absent | 5850 | 158 | 7.7 (2.5) | 3.5 | 1 | 1 | 252 | 7.6 (2.6) | 5.7 | 1 | 1 | 351 | 7.6 (2.6) | 7.9 | 1 | 1 |
| Present | 251 | 11 | 7.0 (2.7) | 6.2 | 1.63 (0.88, 3.01) | 1.51 (0.79, 2.88) | 23 | 6.8 (2.9) | 13.5 | 2.33 (1.52, 3.59) | 2.20 (1.39, 3.49) | 28 | 6.8 2.9) | 16.5 | 1.98 (1.34, 2.91) | 1.88 (1.25, 2.83) |
BMI indicates body mass index; CI, confidence interval; CVD, cardiovascular disease; HR, hazard ratio; HTR, Hormone Trial Randomization; IR, incidence rate; MCI, mild cognitive impairment; 3MSE, Modified Mini‐Mental State Examination; PD, probable dementia; SD, standard deviation; TIA, Transient ischemic attack.
Adjusted for age, education, race, HTR arm, and baseline 3MSE.
Adjusted for age, education, race, HTR arm, baseline 3MSE, alcohol intake, smoking status, physical activity, diabetes status, sleep hours, hypertension status, BMI, depression, waist–hip ratio, hypercholesterolemia, and aspirin use.
Composite of myocardial infarction, angina pectoris, atrial fibrillation, congestive heart failure, coronary bypass surgery, angioplasty, carotid endarterectomy, and peripheral vascular disease.
“Other” includes coronary bypass surgery, angioplasty, carotid endarterectomy, and peripheral vascular disease.