Table 2.
Index Hospitalization and Post‐Index Stroke‐related Costs Among AF and Non‐AF Patients
| Stroke Type/Measure | Overall | AF Cohort | Non‐AF Cohort | Difference (AF vs Non‐AF) | |||||
|---|---|---|---|---|---|---|---|---|---|
| N | Estimate | N | Estimate | N | Estimate | Unadjusted | Adjusted | P Value (Adjusted) | |
| Ischemic Stroke | |||||||||
| Index event LOS, days | 80 083 | 8.0 (±11.5) | 14 251 | 8.3 (±11.7) | 65 832 | 7.9 (±11.4) | 0.4 | 1.1 | 0.0005 |
| Index mortality rate, % | 3.4 | 5.6 | 2.9 | 2.7 | 1.1 | 0.0011 | |||
| Patients surviving index hospitalization | 77 376 | 13 453 | 63 923 | ||||||
| Hospitalization within 30 days, % | 6.5 | 6.9 | 6.4 | 0.5 | 1.4 | <0.0001 | |||
| Patients with continuous enrollment 12 months post‐index | 46 071 | 7072 | 38 999 | ||||||
| Stroke‐related hospitalization within 12 months*, % | 11.6 | 12.3 | 11.5 | 0.8 | 0.7 | 0.1325 | |||
| Mean cost index event | 80 083 | $20 933 (±37 413) | 14 251 | $21 151 (±36 553) | 65 832 | $20 886 (±37 597) | $265 | $3520 | <0.0001 |
| Mean 12‐month total stroke‐related cost* | 46 071 | $25 106 (±39 475) | 7072 | $26 602 (±41 772) | 38 999 | $24 835 (±39 039) | $1767 | $4726 | <0.0001 |
| Hemorrhagic Stroke | |||||||||
| Index event LOS, days | 22 275 | 13.7 (±20.1) | 3052 | 10.7 (±16.1) | 19 223 | 14.1 (±20.6) | −3.4 | 1.0 | <0.0001 |
| Index mortality, % | 18.3 | 23.1 | 17.6 | 5.5 | −1.3 | 0.1436 | |||
| Patients surviving index hospitalization | 18 185 | 2346 | 15 839 | ||||||
| Hospitalization within 30 days, % | 9.7 | 10.0 | 9.6 | 0.4 | 2.8 | 0.0001 | |||
| Patients with continuous enrollment 12 months post‐index | 10 010 | 1162 | 8848 | ||||||
| Stroke‐related hospitalization within 12 months*, % | 14.9 | 16.5 | 14.7 | 1.8 | 1.4 | 0.3179 | |||
| Mean cost index event | 22 275 | $59 054 (±99 512) | 3052 | $38 028 (±66 693) | 19 223 | $62 384 (±103 371) | ($24 356) | $2799 | 0.0214 |
| Mean 12‐month total stroke‐related cost* | 10 010 | $74 462 (±113 962) | 1162 | $54 268 (±79 585) | 8848 | $77 113 (±117 479) | ($22 845) | $7824 | 0.0019 |
| TIA | |||||||||
| Patients with hospitalization index event | |||||||||
| Index event LOS, days | 38 585 | 3.5 (±4.0) | 4759 | 4.1 (±3.7) | 33 826 | 3.4 (±4.1) | 0.7 | 0.3 | <0.0001 |
| Index mortality, % | 0.1 | 0.2 | 0.1 | 0.1 | N/A | N/A | |||
| Patients surviving index hospitalization | 38 541 | 4749 | 33 792 | ||||||
| Hospitalization within 30 days, % | 3.2 | 5.0 | 2.9 | 2.1 | 1.2 | <0.0001 | |||
| Patients with continuous enrollment 12 months post‐index | 26 604 | 3047 | 23 557 | ||||||
| Stroke‐related hospitalization within 12 months*, % | 8.0 | 10.2 | 7.7 | 2.5 | 1.1 | 0.0520 | |||
| Mean cost index event | 38 585 | $8616 (±10 812) | 4759 | $9208 (±4800) | 33 826 | $8533 (±10 128) | $675 | $846 | <0.0001 |
| Mean 12‐month total stroke‐related cost* | 26 604 | $11 931 (±15 617) | 3047 | $13 581 (±17 064) | 23 557 | $11 718 (±15 407) | $1863 | $1890 | <0.0001 |
| Patients With ED Index Event | |||||||||
| Hospitalization within 30 days, % | 19 513 | 8.3 | 1745 | 13.8 | 17 768 | 7.8 | 6.0 | 5.0 | <0.0001 |
| Patients with continuous enrollment 12 months post‐index | 12 956 | 1082 | 11 874 | ||||||
| Stroke‐related hospitalization within 12 months*, % | 8.9 | 14.5 | 8.4 | 6.1 | 5.9 | <0.0001 | |||
| Mean cost index event | 19 513 | $3395 (±3862) | 1745 | $2960 (±3858) | 17 768 | $3438 (±3860) | ($478) | $274 | 0.0011 |
| Mean 12‐month total stroke‐related cost* | 12 956 | $9096 (±14 091) | 1082 | $9651 (±15 531) | 11 874 | $9046 (±13 952) | $605 | $1700 | <0.0001 |
AF indicates atrial fibrillation; ED, emergency department; TIA, transient ischemic attack; LOS, length of stay.
*
Only patients with 12 months continuous enrollment post index; includes index event cost.
Source: Truven MarketScan® Research Databases January 1, 2005 to December 31, 2011.