Figure 16.

IL‐1β plays a pivotal role in adaptive cardiac hypertrophy in response to pressure overload. A through D, Mice were analyzed at 2 weeks after TAC or sham operation under treatment of anti–IL‐1β antibodies (Ab) or control antibodies. A, Heart weight (HW)–to–body weight (BW) ratios (n=7). B, Echocardiographic images. C, Echocardiographic parameters (n=7). D, Hemodynamic data (n=5). *P<0.05 vs sham; ^†P<0.05 vs control antibodies. EF indicates ejection fraction; IL, interleukin; IVSth, interventricular septum thickness; LVEDD, left ventricular end‐diastolic diameter; LVEDP, left ventricular end‐diastolic pressure; LVPWth, left ventricular posterior wall thickness; TAC, transverse aortic constriction.