Table 4.
Correlation Analysis Between Lipoproteins and CTA‐Derived Quantitative Coronary Atherosclerotic Plaque Parameters.
Biomarker | Univariate r Value | Univariate P Value | Multivariable β‐Coefficient | Multivariable P Value | Adjusted P Value | |
---|---|---|---|---|---|---|
CAP Volume | Pre‐α3‐HDL | −0.28 | 0.05 | −8.36 | 0.12 | 0.12 |
Pre‐β2‐HDL% | −0.29 | 0.04 | −24.65 | 0.02 | 0.02 | |
Pre‐β2‐HDL | −0.29 | 0.04 | −16.66 | 0.02 | 0.02 | |
CAP% | Pre‐α4‐HDL | −0.28 | 0.04 | −4.14 | 0.24 | 0.24 |
Pre‐α4‐HDL% | −0.28 | 0.05 | −7.14 | 0.13 | 0.13 | |
TC | −0.29 | 0.04 | −0.02 | 0.77 | 0.77 | |
sd‐LDL | −0.30 | 0.03 | −0.31 | 0.19 | 0.19 | |
ApoB | −0.33 | 0.02 | −0.08 | 0.47 | 0.47 | |
Pre‐α3‐HDL | −0.37 | <0.01 | −2.93 | 0.03 | 0.03 | |
Pre‐α3‐HDL% | −0.37 | <0.01 | −4.4 | 0.01 | 0.01 | |
HD‐NCP% | Pre‐α3‐HDL | 0.40 | <0.01 | 2.98 | 0.01 | 0.01 |
Pre‐α3‐HDL% | 0.39 | <0.01 | 4.32 | <0.01 | <0.01 | |
ApoB | 0.31 | 0.03 | 0.07 | 0.46 | 0.46 | |
sd‐LDL | 0.3 | 0.03 | 0.3 | 0.17 | 0.17 | |
Pre‐α4‐HDL | 0.29 | 0.04 | 3.99 | 0.21 | 0.21 | |
TC | 0.27 | 0.05 | 0.02 | 0.76 | 0.76 | |
LD‐NCP% | Triglycerides | 0.34 | 0.01 | 0.01 | 0.18 | 0.18 |
Α3‐HDL% | 0.32 | 0.02 | 0.12 | 0.10 | 0.10 | |
ApoB | 0.29 | 0.04 | 0.01 | 0.7 | 0.7 | |
TC | 0.24 | 0.08 | 0 | 0.91 | 0.91 | |
HDL‐C | −0.34 | 0.01 | −0.1 | 0.07 | 0.07 | |
A2‐HDL% | −0.34 | 0.02 | −0.16 | 0.12 | 0.12 | |
A1‐HDL% | −0.28 | 0.05 | −0.12 | 0.20 | 0.20 | |
MLA | Lp(a) | 0.27 | 0.05 | 0.02 | 0.08 | 0.08 |
%AS | Lp(a) | −0.14 | 0.31 | −0.05 | 0.64 | 0.64 |
Pre‐α2‐HDL | −0.30 | 0.03 | −1.17 | 0.23 | 0.23 | |
MLD | Lp(a) | 0.23 | 0.10 | 0 | 0.32 | 0.32 |
Pre‐α2‐HDL | 0.04 | 0.77 | −0.03 | 0.28 | 0.28 | |
Pre‐β2‐HDL% | 0.30 | 0.03 | 0.21 | 0.02 | 0.02 | |
%DS | Pre‐α2‐HDL% | −0.28 | 0.05 | −1.33 | 0.32 | 0.32 |
Pre‐α3‐HDL | −0.29 | 0.04 | −1.88 | 0.11 | 0.11 | |
Pre‐β2‐HDL | −0.30 | 0.03 | −3.27 | 0.04 | 0.04 |
Adjusted P values represent adjusting for age, sex, BMI, diabetes, and medication use. One multivariable model was fit for each biomarker separately. AS indicates area stenosis; BMI, body mass index; CAP, calcified plaque; CTA, computed tomography angiography; DS, diameter stenosis; HDL, high‐density lipoprotein; HD‐NCP, high‐density noncalcified plaque; LD‐NCP, low‐density noncalcified plaque; Lp(a), lipoprotein a; MLA, minimal luminal area; MLD, minimal lumen diameter; sd‐LDL, small, dense low‐density lipoprotein; TC, total cholesterol.