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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: Semin Immunol. 2013 Nov 15;25(4):10.1016/j.smim.2013.10.022. doi: 10.1016/j.smim.2013.10.022

Figure 3. Functional plasticity of mature CD4 T cells.

Figure 3

Antigen-stimulated CD4 T cells functionally differentiate into various Th subsets, driven by subset-specific transcription factors and cytokines. Repeated antigen stimulation leads to the loss of ThPOK expression and the induction of the Runx3-driven CTL polarization.