Table 1.
NF-κB and STAT3 target genes.
| NF-κB | STAT3 |
|---|---|
| Cell growth & proliferation | |
|
| |
| c-Myc | c-Myc |
| MDM2 | Pim1 |
| Cyclin D1 | Cyclin D1 |
| Pim1 | AKT |
| AKT | JunB |
| p53↓ | p53↓ |
|
| |
| Apoptosis & drug resistance | |
|
| |
| Bcl-2 | Bcl-2 |
| Bcl-XL | Bcl-X L |
| Survivin | Survivin |
| cIAP2 | cIAP2 |
| MGMT | MDR1 |
| Mcl-1 | |
| STAT3 | |
|
| |
| Cell migration & invasion | |
|
| |
| MMP-9 | MMP-2 |
| ICAM-1 | MMP-9 |
| VCAM-1 | |
| E-selectin | |
|
| |
| Angiogenesis | |
|
| |
| I L- 8 | VEGF |
| VEGF | HIF-1α |
| iNOS | |
| COX-2 | |
|
| |
| Cytokines/signaling pathways | |
|
| |
| IL-6 | IL-10 |
| IL-10 | IL-17 |
| TNF-α | IL-27 |
| Sonic Hedgehog | Notch1 |
| Jagged-1 | |
| δ-like ligand | |
cIAP: Cellular inhibitor of apoptosis protein; iNOS: Inducible nitric oxide synthase; MDR: Multi-drug resistance; MGMT: O6-methylguanine–DNA methyltransferase; MMP: Matrix metalloproteinase; STAT: Signal transducer and activator of transcription.