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A model for MMSET regulation of miR-126* and c-MYC expression. MMSET, in collaboration with KAP1 and HDAC proteins among others, binds the miR-126/126* locus, promoting chromatin modifications that lead to gene repression. Decreased levels of miR-126* release the 3′-UTR region of c-MYC mRNA, allowing for an increased translation of the transcript. As a result, elevated c-MYC protein expression promotes the proliferation of t(4;14) MM cells.
