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. 2013 Dec;5(6):E254–E307. doi: 10.3978/j.issn.2072-1439.2013.11.28

Table 5. PICO questions relating to palliative and supportive care for malignant mesothelioma.

R × S1 Does malignant mesothelioma have a high symptomatic burden when compared to other malignant diagnoses?
R × S2 Do people living with malignant mesothelioma need symptom palliation from the time of diagnosis?
R × S3 What are the different characteristics of pain frequently encountered in malignant mesothelioma?
R × S4 What are the key modalities for treating pain in malignant mesothelioma?
R × S5 Do early interventional pain techniques offer advantages over systemic therapies for malignant mesothelioma patients?
R × S6 What are the interventions to manage dyspnoea in malignant mesothelioma?
R × S7-R × S10 See Chapter 4
R × S11 Does chemotherapy for malignant mesothelioma improve quality of life or functional status independent of its effect on tumour response?
R × S12 What are the psychosocial needs of patients with malignant mesothelioma?
R × S13 What are the psychosocial needs of carers and families of people diagnosed with malignant mesothelioma?
R × S14 For Q12 and 13, do these needs change in relation to proximity to death?
R × S15 Are there effective psychosocial interventions to assist people diagnosed with malignant mesothelioma and/or their carers and families to cope with their illness? See also RxS5.
R × S16 What are the legal compensation issues for patients and/or families with malignant mesothelioma?
R × S17 Do people diagnosed with malignant mesothelioma use complementary therapies to treat or manage their illness?
R × S18 Do people with malignant mesothelioma use alternate therapies to treat or manage their illness?
R × S19 Do health care providers support the use of complementary and/or alternate therapies by people diagnosed with malignant mesothelioma?
R × 20 Does nutritional assessment and support improve survival and/or quality of life in patients with mesothelioma?
R × 21 Do exercise programs improve survival and/or quality of life in patients with mesothelioma?