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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Nat Med. 2013 Dec 8;20(1):10.1038/nm.3416. doi: 10.1038/nm.3416

Figure 3. 13C MR spectrum from an untreated subcutaneous EL4 lymphoma tumor.

Figure 3

The spectrum is the sum of 54 transients acquired over a period of 6 s, ~15 s after intravenous injection of 0.4 mL 200 mM hyperpolarized [U-2H, U-13C]glucose. The small difference in signal-to-noise ratios between the glucose and lactate regions of the summed spectrum is the result of interleaved signal acquisition from the glucose and lactate regions, with more sampling of the lactate region (see Methods). The inset shows a ×40 magnification of the 160–220 p.p.m. region. This shows bicarbonate C1 (~164 p.p.m., HCO3−), 6-phosphogluconate C1 (~182 p.p.m., 6PG), lactate C1 (~185 p.p.m.) and dihydroxyacetone phosphate C2 (~214 p.p.m., DHAP). The signals from hyperpolarized [U-2H, U-13C]glucose are located between 63 and 99 p.p.m..