Table 1. 17 HDL studies for meta analysis.
| Study ID | Strains | Conditions | Age | Sex | # Strains | # Samples | # Sig Loci | Ref |
| HMDPxB-chow(M) | (HMDP×BL/6) F1 | Leiden/CETP TG,chow diet | 8 weeks | M | 97 | 516 | 1 | U |
| HMDPxB-chow(F) | (HMDP×BL/6) F1 | Leiden/CETP TG, chow diet | 8 weeks | F | 95 | 468 | 0 | U |
| HMDPxB-ath(M) | (HMDP×BL/6) F1 | Leiden/CETP TG, highfat diet | 24 weeks | M | 97 | 408 | 0 | U |
| HMDPxB-ath(F) | (HMDP×BL/6) F1 | Leiden/CETP TG, highfat diet | 24 weeks | F | 93 | 457 | 3 | U |
| HMDP-chow(M) | HMDP | chow diet | 12 weeks | M | 111 | 749 | 6 | [18] |
| HMDP-fat(M) | HMDP | highfat diet | 16 weeks | M | 106 | 586 | 0 | [14] |
| HMDP-fat(F) | HMDP | highfat diet | 16 weeks | F | 92 | 475 | 0 | [44] |
| BxD-db-12(M) | (DBA×BL/6) F2 | BXD db/db, chow diet | 12 weeks | M | 125 | 125 | 0 | [45] |
| BxD-db-12(F) | (DBA×BL/6) F2 | BXD db/db, chow diet | 12 weeks | F | 122 | 122 | 0 | [45] |
| BxD-db-5(M) | (DBA×BL/6) F2 | BXD db/db, chow diet | 5 weeks | M | 109 | 109 | 1 | [45] |
| BxD-db-5(F) | (DBA×BL/6) F2 | BXD db/db, chow diet | 5 weeks | F | 139 | 139 | 0 | [45] |
| BxH-apoe(M) | (C3H×BL/6) F2 | BXH Apoe -/- | 24 weeks | M | 161 | 161 | 0 | [46] |
| BxH-apoe(F) | (C3H×BL/6) F2 | BXH Apoe -/- | 24 weeks | F | 174 | 174 | 0 | [46] |
| BxH-wt(M) | (C3H×BL/6) F2 | BXH wildtype, highfat diet | 20 weeks | M | 164 | 164 | 0 | [47] |
| BxH-wt(F) | (C3H×BL/6) F2 | BXH wildtype, highfat diet | 20 weeks | F | 144 | 144 | 0 | [47] |
| CxB-ldlr(M) | (BALB/cJ×BL/6) F2 | CXB LDLR -/-, highfat diet | 12 weeks | M | 124 | 124 | 0 | U |
| CxB-ldlr(F) | (BALB/cJ×BL/6) F2 | CXB LDLR -/-, highfat diet | 12 weeks | F | 64 | 64 | 0 | U |
Seventeen HDL studies are combined in the meta analysis. U in the Ref column represents a data set that is not yet published. Mice for the HMDPxB panel were created by breeding females of the various HMDP inbred strains to males carrying transgenes for both Apoe Leiden and for human Cholesterol Ester Transfer Protein (CETP) on a C57BL/6 genetic background. The Leiden/CETP transgenes [48], [49] cause high total cholesterol level and high LDL cholesterol level in the circulation, along with reduced HDL cholesterol. BxD db/db denotes a population of F2 mice from a cross between C57BL/6 DBA/2 with homozygous deficiency in leptin receptor (db/db), which results in obese mice. BxH Apoe -/- denotes denotes a population of F2 mice from a cross between C57BL/6 and C3H also carrying a deficiency in apolipoprotein E. CxB LDLR -/- denotes a population of F2 mice from a cross between C57BL/6 and BALB/cBy also carrying a deficiency in LDL receptor, which results in high LDL cholesterol level in the circulation BXH wildtype denotes a population of F2 mice from a cross between C57BL/6 and C3H.