Table 2. NGS meta-analysis: first 15 most frequently mutated genes in each molecular subtype.
| Basal | ERBB2 | Luminal A | Luminal B | ||||
| (N = 132) | (N = 71) | (N = 248) | (N = 134) | ||||
| mutated genes | frequency (%) | mutated genes | frequency (%) | mutated genes | frequency (%) | mutated genes | frequency (%) |
| TP53 * | 71% | TP53 * | 68% | PIK3CA * | 43% | PIK3CA | 31% |
| TTN | 19% | PIK3CA | 37% | MAP3K1 * | 13% | TP53 | 29% |
| USH2A * | 11% | MUC16 | 14% | GATA3 | 13% | GATA3 | 13% |
| FLG | 7% | LRP1 * | 8% | TP53 | 11% | TTN | 12% |
| MUC16 | 7% | ERBB3 * | 8% | TTN | 9% | RYR2 | 7% |
| PIK3CA | 7% | DNAH11 * | 8% | CDH1 | 9% | RELN | 5% |
| MUC17 | 6% | LRP2 | 8% | MLL3 | 7% | FAT3 | 5% |
| DNAH7 * | 5% | TTN | 8% | MAP2K4 | 6% | MLL3 | 5% |
| FAT3 | 5% | ATP1A4 * | 7% | NCOR1 | 5% | MUC16 | 5% |
| SYNE1 | 5% | KIAA1109 * | 7% | AKT1 | 4% | KCNB2 * | 4% |
| DST | 5% | CACNA1E | 7% | RUNX1 | 4% | CENPE | 4% |
| F5 | 5% | FLG | 7% | PTEN | 4% | DMD | 4% |
| COL12A1 | 5% | MLL3 | 7% | MUC16 | 4% | MUC17 | 4% |
| COL6A3 | 5% | ASPM * | 6% | CTCF | 4% | CDH1 | 4% |
| APOB | 5% | DCC * | 6% | NEB | 4% | MAP3K1 | 4% |
Gene mutation associated with the corresponding molecular subtype.