Figure 6. HyBNAR/MX2-LUC mice are both sensitive and responsive to human IFN-Is.

Transgenic mice expressing the luciferase reporter gene under the control of the MX2 promoter (MX2-LUC) were interbred with the HyBNAR mice. The HyBNAR/MX2-LUC mice (upper panel) were injected IP with increasing concentrations of human IFNβ. After 6 hours, mice were injected with luciferin, anaesthetized and live luminosity was measured by an image capturing device (IVIS spectrum). For comparative purposes MX2-LUC mice without the HyBNAR transgene were also analyzed (bottom panel).