Figure 1. TM-IEC C1galt -/- mice are not spontaneously colitic but more susceptible to DSS-induced intestinal inflammation.
(A) Histological analysis by HE, AB-PAS and Tn antibody staining of sections taken ten days post knockout induction from ileal and colonic tissue of wild type (WT) and TM-IEC C1galt -/- (KO) mice. Scale bars indicate 100 µm. (B) Body weight and (C) DAI during DSS treatment and recovery period (n = 16 per genotype for day 0, two mice sacrificed every day during DSS treatment; Data shows mean ± SEM; ** p<0.01, *** p<0.001).