Table 1. Invasive hemodynamic analysis of 6 and 10 weeks after AAB in wild-type and DPP4-deficient rats.
| Wild-type | DPP4-deficiency | |||
| Sham | AAB | Sham | AAB | |
| 6 week | ||||
| LVSP (mmHg) | 147.9±6.0 | 172.8±4.9* | 153.9±2.9 | 185.8±6.5† |
| LVEDP (mmHg) | 4.5±0.3 | 5.6±0.5 | 4.9±0.5 | 5.3±1.0 |
| LVDP (mmHg) | 143.4±5.8 | 167.2±5.2* | 148.3±3.2 | 180.5±7.5† |
| HR (bpm) | 396.1±10.8 | 389.9±21.5 | 405.4±8.5 | 395.4±24.0 |
| +max dPdt (mmHg/s) | 14243.5±1069.4 | 13778.4±695.6 | 14445.6±114.6 | 13974.1±253.7 |
| −min dPdt (mmHg/s) | 12700.2±1129.1 | 12229.8±753.9 | 12525.8±193.9 | 12539.9±168.9 |
| LVESV (µL) | 36.2±5.7 | 81.4±15.9* | 36.2±2.0 | 43.3±9.5# |
| LVEDV (µL) | 143.7±7.2 | 161.1±7.7 | 155.9±18.8 | 141.8±3.4 |
| SV (µL) | 107.5±3.1 | 79.7±11.9* | 119.7±17.6 | 98.4±7.9# |
| %EF | 75.3±2.9 | 50.5±10.7* | 75.9±1.9 | 69.3±7.4# |
| ESPVR slope (mmHg/µL) | 1.21±0.05 | 2.30±0.45* | 1.31±0.11 | 1.97±0.05† |
| EDPVR slope (mmHg/µL) | 0.0220±0.0026 | 0.0416±0.0089* | 0.0230±0.0031 | 0.0194±0.0083 |
| 10 week | ||||
| LVSP (mmHg) | 136.2±7.2 | 119.6±8.9@ | 141.7±3.5 | 140.3±7.2& |
| LVEDP (mmHg) | 4.7±0.5 | 6.8±1.9@ | 4.5±0.1 | 4.4±0.9& |
| LVDP (mmHg) | 131.4±7.1 | 112.8±8.1@ | 137.2±4.2 | 135.9±8.1& |
| HR (bpm) | 378.1±35.0 | 366.3±13.3 | 393.7±15.2 | 385.3±17. 3 |
| +max dPdt (mmHg/s) | 11353.8±652.5 | 8568.2±483.9@ | 10924.9±945.5 | 10039.7±246.4& |
| −min dPdt (mmHg/s) | 8301.3±683.9* | 6994.9±519.9@ | 10696.8±1028.7 | 8644.8±850.2& |
| LVESV (µL) | 64.6±11.4 | 125.3±2.8@ | 67.5±7.9 | 89.2±14.7& |
| LVEDV (µL) | 194.9±26.7 | 231.1±19.7 | 213.2±38.7 | 249.2±37.3 |
| SV (µL) | 130.2±16.2 | 105.9±18.1@ | 145.7±31.2 | 159.9±22.7& |
| %EF | 67.5±2.5 | 44.7±4.6@ | 67.6±2.2 | 64.4±0.9& |
| ESPVR slope (mmHg/µL) | 1.10±0.35 | 0.59±0.20@ | 1.12±0.23 | 0.82±0.20& |
| EDPVR slope (mmHg/µL) | 0.0145±0.0033 | 0.0126±0.0023 | 0.0172±0.0069 | 0.0168±0.0027 |
Values are means ± SE (n = 8) MAP : mean arterial pressure, HR : heart rate, LVSP : left ventricular systolic pressure, LVEDP : left ventricular end-diastolic pressure, DP : development pressure, +dP/dt and −dP/dt : maximal slope of the systolic pressure increment and diastolic pressure decrement, respectively, Ves : end-systolic volume, Ved : end-diastolic volume, SV : stroke volume, EF : ejection fraction, ESPVR : end-systolic pressure–volume relation, and EDPVR : end-diastolic pressure–volume relation.
p<0.05 vs. wild-type 6 week sham,
# p<0.05 vs. wild-type 6 week AAB,
@ p<0.05 vs. wild-type 10 week sham,
& p<0.05 vs. wild-type 10 week AAB,
p<0.05 vs. DPP4 deficiency 6 week sham.